Autistic traits in women with polycystic ovary syndrome

Hergüner, Sabri̇; Harmanci, Hatice; Hergüner, Arzu; Toy, Harun

doi:10.1016/j.rasd.2012.01.003

Cited by 14 publications

(11 citation statements)

References 25 publications

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“…Girls with CAH scored significantly higher on the total AQ and on subscales measuring Social Skills and Imagination than their unaffected sisters (Knickmeyer et al, ). AQ total and communication scores were statistically higher in women with PCOS (Hergüner et al, ) and in children of women with PCOS (Palomba et al, ). These findings support that early exposure to high levels of androgens may influence both AAM and some autistic traits.…”

Section: Discussionmentioning

confidence: 97%

Association between age at menarche and autistic traits in Turkish university students

Hergüner

2015

American J Hum Biol

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Section: Discussionmentioning

confidence: 97%

Association between age at menarche and autistic traits in Turkish university students

Hergüner

2015

American J Hum Biol

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“…Women with autism also have increased levels of androstenedione (an adrenal androgen) 18 , elevated levels of luteinizing hormone (LH), and an increased free androgen index (FAI) compared to typical controls 19 . In the second category, women with PCOS score higher on measures of autistic traits 20 , as do their daughters, but not their sons 21 . A recent population study in Sweden found a significantly increased risk of autism in children of mothers with PCOS, which was exacerbated by comorbid maternal metabolic syndrome 22 .…”

Section: Introductionmentioning

confidence: 98%

Polycystic ovary syndrome and autism: A test of the prenatal sex steroid theory

et al. 2018

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Elevated levels of prenatal testosterone may increase the risk for autism spectrum conditions (autism). Given that polycystic ovary syndrome (PCOS) is also associated with elevated prenatal testosterone and its precursor sex steroids, a hypothesis from the prenatal sex steroid theory is that women with PCOS should have elevated autistic traits and a higher rate of autism among their children. Using electronic health records obtained from the Clinical Practice Research Datalink (CPRD) in the UK between 1990 and 2014, we conducted three matched case-control studies. Studies 1 and 2 examined the risk of PCOS in women with autism (n = 971) and the risk of autism in women with PCOS (n = 26,263), respectively, compared with matched controls. Study 3 examined the odds ratio (OR) of autism in first-born children of women with PCOS (n = 8588), matched to 41,127 controls. In Studies 1 and 2 we found increased prevalence of PCOS in women with autism (2.3% vs. 1.1%; unadjusted OR: 2.01, 95% CI: 1.22–3.30) and elevated rates of autism in women with PCOS (0.17% vs. 0.09%, unadjusted OR: 1.94 CI: 1.37–2.76). In Study 3 we found the odds of having a child with autism were significantly increased, even after adjustment for maternal psychiatric diagnoses, obstetric complications, and maternal metabolic conditions (unadjusted OR: 1.60, 95% CI: 1.28–2.00; adjusted OR: 1.35, 95% CI: 1.06–1.73). These studies provide further evidence that women with PCOS and their children have a greater risk of autism.

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“…Se ha encontrado una relación estadística entre la presencia de rasgos autistas, depresión, ansiedad (44) y problemas de comunicación en mujeres con SOP, en contraste con sujetos control, condición probablemente asociada a que ambas patologías comparten una presencia de andrógenos elevada en la etapa fetal (2). Otro estudio encontró diferencias significativas en los puntajes obtenidos en una prueba para medir coeficiente intelectual entre las pacientes con SOP y las pacientes del grupo control, aunque los autores señalan que no se puede concluir que dicha distinción obedezca a síntomas específicos de la enfermedad o acambios en el estado de ánimo (12).…”

Section: Resultsunclassified

“…El síndrome de ovario poliquístico (SOP) se ha convertido en un grave problema de salud pública, siendo el más común de los desórdenes endocrinos en mujeres en edad reproductiva (1), con una proporción de una de cada cinco personas en esta población (2). Es una enfermedad de etiología multifactorial, comórbida en muchos casos con la obesidad, la dislipidemia, los desórdenes cardiovasculares, la hiperplasia endometrial, los desórdenes del periodo menstrual e infertilidad (3), el cáncer endometrial (4), el cáncer de mama (5), y procesos pro-inflamatorios (6); esta condición, a su vez, afecta la tolerancia a la metabolización de la glucosa (7), la resistencia a la insulina y potencia el hiperandrogenismo (1).…”

Section: Introductionunclassified

El síndrome de ovario poliquístico: aspectos psicológicos

Gómez-Acosta¹,

Alpi²,

Quiceno³

2015

Rev. chil. obstet. ginecol.

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La gran mayoría de la literatura científica sobre el síndrome de ovario poliquístico (SOP) ha utilizado un enfoque bio-médico para analizar esta enfermedad. En América Latina, y específicamente en idioma español, hay escasa información sobre las relaciones del SOP con factores psicológicos. Objetivo: Analizar este trastorno ginecológico de origen endocrino y su asociación con diferentes factores psicológicos, así como su abordaje integral. Método: Se realizó una búsqueda en bases de datos en los últimos años con los términos "SOP", "calidad de vida", "ansiedad", "depresión", "imagen corporal" y "disfunción sexual". Resultados: El SOP es una enfermedad multifactorial que se ha vinculado a la depresión, la ansiedad, el estrés, la insatisfacción de la imagen corporal, trastornos sexuales y de la alimentación, el funcionamiento cognitivo, calidad de vida y el bienestar psicológico; la co-ocurrencia de este tipo de situaciones psicológicas alimenta la condición somática en mención. Conclusión: El abordaje psicológico puede complementar las acciones preventivas y terapéuticas que influyen en la efectividad del tratamiento y el bienestar subjetivo informado por los pacientes. PALABRAS CLAVES: Ovario poliquístico, emociones negativas, imagen corporal, trastornos de la alimentación, calidad de vida SUMMARY Background: The vast majority of the scientific literature on polycystic ovary syndrome (PCOS) have used a bio-medical approach to analyzing this disease. In Latin America, specifically in Spanish, little is known about the relationship of PCOS with psychological factors. Aim: To analyze this gynecological disorder of endocrine origin and their association with different psychological factors and their comprehensive approach. Method: A search was performed in databases in recent years with the terms "PCOS", "quality of life", "anxiety", "depression", "body image" and "sexual dysfunction." Results: PCOS is a multifactorial disease that has been linked to depression, anxiety, stress, dissatisfaction with body image, sexual and eating disorders, cognitive functioning, quality of life and psychological well-being; the co-occurrence of such psychological situations feed the somatic condition analyzed. Conclusion: The psychological approach can complement the preventive and therapeutic actions that influence the effectiveness of treatment and subjective well-being reported by patients.

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Autistic traits in women with polycystic ovary syndrome

Cited by 14 publications

References 25 publications

Association between age at menarche and autistic traits in Turkish university students

Association between age at menarche and autistic traits in Turkish university students

Polycystic ovary syndrome and autism: A test of the prenatal sex steroid theory

El síndrome de ovario poliquístico: aspectos psicológicos

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