Auto-agglutination in albumin

Powell, D. E. B.; Rees, Chet R.

doi:10.1136/jcp.18.2.212

Cited by 7 publications

(4 citation statements)

References 2 publications

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“…Successful transfusions have been accomplished in the presence of albumin autoagglutinating factor.7~ 11,17 When the inhibition of agglutination by ACD and the ability to obtain compatible units by simply delaying the first step of the crossmatch are considered, the saline-agglutinating factor also would not appear to be a contraindication to transfusion. Our one patient who was transfused (patient 3) suffered no ill effects.…”

Section: Discussionmentioning

confidence: 99%

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Agglutination of Erythrocytes Freshly Washed with Saline Solution

et al. 1972

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Four cases are reported in which the patients' sera agglutinated all erythrocytes tested, including their own, provided the cells first had been freshly washed with saline solution. The reactions of these sera are described and compared with other reports of panagglutination and autoagglutination specifically related to the use of common laboratory solutions (albumin, saline, citrate, or oxalate).

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Section: Discussionmentioning

confidence: 99%

“…5 albumin,'! 7-98 11,[14][15][16] and citrate or oxalate.10 I n the past year we have studied four patients whose sera agglutinated all erythrocytes tested, including their own, provided the cells had been freshly washed with saline solution.…”

Section: Froin the Mayo Clinic And Mayo Foundation Rochester Minnesotamentioning

confidence: 99%

Agglutination of Erythrocytes Freshly Washed with Saline Solution

et al. 1972

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“…The common property of these albumin agglu tinating sera is the ability to cause agglutination of all red blood cells, including auto-agglutination, in an albumin medium. Previous studies have shown that the property does not have the characteristics of a blood group antibody, there is no reactivity with colloids other than albumin, the direct Coombs test is negative, and the reaction is not complement dependent [1][2][3][4][5][6][7][8][9]. Individuals with this abnormality are usually identified when transfusion is anticipated and an albumin crossmatch is performed.…”

Section: Introductionmentioning

confidence: 99%

Mechanism of the Albumin Agglutination Phenomenon

Golde¹,

McGinniss²,

Holland³

1969

Vox Sanguinis

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The albumin agglutination phenomenon is due to antibodies which cause agglutination of all human red cells when these cells are suspended in an albumin medium. Two sera with this property were studied. We suggest that the reaction is due to non-specific adsorption of antigen-antibody complex onto red cells. The antibody is a gamma globulin directed at albumin which has been altered by the addition of acetyl tryptophanate or caprylate. These chemicals are added as stabilizers in the manufacture of albumin to prevent dénaturation when the albumin is heated. Since unaltered (native) albumin does not react with these antibodies, blood or plasma transfusion to patients with this serologic abnormality should present no unusual hazard. A non-reactive albumin should be used in crossmatching blood for such patients. Therapeutic human serum albumin and plasma products containing stabilized albumin are probably contraindicated in these patients.

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“…The albumin auto-agglutinating phenomenon, first described by Weiner [12,13] and his associates, must be of infrequent occurrence, for although albumin is frequently used as a suspending medium for test cells, only a few further examples of this phenomenon have been recorded [1,2,3,4,5,6,8,11,14], The property is characterized by the ability of the patients' sera to react with their own and all other red cells but only when the cells are suspended in an albumin medium.…”

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confidence: 99%