Auto-Immunity in Man and Homologous Disease in Mice in Relation to the Malignant Lymphomas

Clonal Evolution in Two Patients with Autoimmune Disease and Lymphoreticular Neoplasia

“…This may result in an immunoproliferative response (autoimmunity), in a localised (lympho-sarcomatous) process or a generalised (leukaemic) disease." This was in keeping with the hypothesis of Kaplan and Smithers (1959) who suggested that autologous tumour cells have undergone antigen deletion which means that they would attack normal lymphocytes bearing such antigens. Case I fits these theories much better than Case II.…”

Studies on Delayed Hypersensitivity in Hodgkin's Disease*

“…A viral etiology has been repeatedly proposed but never established (29), and an immunologic mechanism involving a graftversus-host reaction has been recently suggested (30,31). Although the significance of the cutaneous anergy of Hodgkin's disease remains to be established, it should be explained by a satisfactory disease mechanism.…”

Immunopathology of Hodgkin’s Disease

“…An early hypothesis was that the inflammatory cells were reacting against the Reed-Stern berg cells, a process akin to graft-versus-host disease [51,52], There is, however, little experimental evidence for such a view. Another hypothesis is that the inflammatory cell population is recruited into the tumor by production of as yet unidentified lymphokine-like substances [20], A similar phenom enon is observable in a thymoma, a neo plasm of thymic epithelium which 'recruits' nonneoplastic lymphocytes of normal thymic phenotype [53], The interaction be tween Rccd-Stcrnbcrg cells and normal lym phocytes in some way results in the charac teristic clinicopathologic features of Hodg kin's disease.…”