Autoantibodies in male homosexuals and HIV infection

Antiphospholipid syndrome associated with infections: clinical and microbiological characteristics

“…In 1997, Canoso et al (1987) reported on aCL positivity with HTLV-III infection. In 1992, the association of aCL with HIV infection in male homosexuals was reported (Argov et al, 1991) and several studies since then have confirmed these original findings (Coll et al, 1992;Falco et al, 1993;Weiss et al, 1995;De Larran˜aga et al, 1999;Petrovas et al, 1999;Gonzales et al, 1999;Silvestris et al, 1996;Guerin et al, 1999;Loizou et al, 2003).…”

Autoreactive Response in Seronegative Homosexual Men at High Risk for HIV Infection

“…5. Proliferative responses to gpl60 synthetic peptides ( , no peptide; 0, aa 112-124; ED, aa 315-329; S3, aa 429-443; 0, aa 835-848) of PBMC of three high risk subjects (1)(2)(3) with the non-"single hit" kinetics and three normal subjects (4)(5)(6) with the "single hit" kinetics. Responses were detected by [3H]thymidine uptake.…”

“…Numerous studies have demonstrated an imbalance of autoreactive T cells in patients with autoimmune diseases and diseases with an autoimmune component (2,9,14,15,21). Recently, Argov et al (1) demonstrated that patients with acquired immunodeficiency syndrome (AIDS) and AIDS-related complex (ARC), as well as asymptomatic HIV+ male homosexual subjects, have significantly elevated levels of several autoantibodies in their serum.…”

Different Dysregulations of the Natural Antibody Repertoire in Treated and Untreated HIV-1 Patients

“…These abnormalities include the presence of serum antibodies against phospholipids [26,27], antineutrophil cytoplasmic autoantibodies [28,29], antibodies to HLA [30], anti-glomerular basement antibodies [29], anti-various nuclear antigens and DNA [28,31,32], anti-denatured collagen [33], and rheumatoid factor [34]. It is thus conceivable that the high frequency of these autoimmune phenomena is favored by dysregulations of the natural antibody network described here.…”