Autoantibodies to the alpha/beta T-cell receptors in human immunodeficiency virus infection: dysregulation and mimicry.

Lake, Douglas F.; Schluter, Samuel F.; Wang, Ena; Bernstein, Ralph M.; Edmundson, Allen B.; Marchalonis, John J.

doi:10.1073/pnas.91.23.10849

Cited by 38 publications

(21 citation statements)

References 30 publications

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“…Peptide libraries are important tools for epitope mapping, mimotope discovery, and the identification of new binding sites and ligands (173,174). Selected peptides are useful as diagnostic reagents, affinity ligands, or immunogens for monoclonal antibodies, anti-epitope production or vaccine preparation (175)(176)(177)(178)(179). Mimotopes, mainly obtained by random peptide libraries, are peptides able to mimic the reaction between epitopes in antigens and the antibodies they elicit (180).…”

Section: Peptidic Ligandsmentioning

confidence: 99%

Antibodies and Genetically Engineered Related Molecules: Production and Purification

Roque

Lowe

Taipa³

2004

Biotechnol. Prog.

328

203

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Antibodies and antibody derivatives constitute 20 % of biopharmaceutical products currently in development, and despite early failures of murine products, chimeric and humanized monoclonal antibodies are now viable therapeutics. A number of genetically engineered antibody constructions have emerged, including molecular hybrids or chimeras that can deliver a powerful toxin to a target such as a tumor cell. However, the general use in clinical practice of antibody therapeutics is dependent not only on the availability of products with required efficacy but also on the costs of therapy. As a rule, a significant percentage (50-80%) of the total manufacturing cost of a therapeutic antibody is incurred during downstream processing. The critical challenges posed by the production of novel antibody therapeutics include improving process economics and efficiency, to reduce costs, and fulfilling increasingly demanding quality criteria for Food and Drug Administration (FDA) approval. It is anticipated that novel affinity-based separations will emerge from the development of synthetic ligands tailored to specific biotechnological needs. These synthetic affinity ligands include peptides obtained by synthesis and screening of peptide combinatorial libraries and artificial non-peptidic ligands generated by a de novo process design and synthesis. The exceptional stability, improved selectivity, and low cost of these ligands can lead to more efficient, less expensive, and safer procedures for antibody purification at manufacturing scales. This review aims to highlight the current trends in the design and construction of genetically engineered antibodies and related molecules, the recombinant systems used for their production, and the development of novel affinity-based strategies for antibody recovery and purification.

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Section: Peptidic Ligandsmentioning

confidence: 99%

Antibodies and Genetically Engineered Related Molecules: Production and Purification

Roque

Lowe

Taipa³

2004

Biotechnol. Prog.

328

203

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“…This viral protein, along with the Nef protein, appears to possess B cell stimulatory activity (Chirmule et al, 1990. There is evidence of a crossreaction between a conserved segment of the V3 loop of HIV-1 gp-120 and the human T cell receptor beta chain (Lake et al, 1994). In addition, direct mimicry of MHC molecules by the viral envelope has been suggested (Habeshaw, 1994;Habeshaw et al, 1999;Susal et al, 1996b;.…”

Section: Sequence Similarities Hypothesized To Contribute Direc¹¸> Tomentioning

confidence: 97%

Evolutionary Stable Strategy: A Test for Theories of Retroviral Pathology which are Based upon the Concept of Molecular Mimicry

Powell

DeMartini

Azari

et al. 2000

Journal of Theoretical Biology

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“…This mechanism, observed in HIVpositive subjects in both acute and chronic stages of the disease [141,79], was thought to contribute to lymphopenia and to immune dysfunction through massive CD4+ Tlymphocyte killing [156,54,165]. In Fig.…”

Section: Lymphocytotoxic Antibodiesmentioning

confidence: 97%

“…HIV antigens also present similarities to surface molecules found on immune cells. V3 loop domain from HIV-gp120 shares homology with a conserved fragment of Vbeta domain of T cell receptor (TCR) [79]. HIV-gp41 protein (ELDKWAS epitope) is highly homologue to a conserved domain of human HLA type II molecule; it may induce cross-reactive antibodies in infected subjects [53].…”

Section: Mimicry: When Form Shapes Activitymentioning

confidence: 99%

Is Autoimmunity a Component of Natural Immunity to HIV?

Russo¹,

Lopalco

2006

CHR

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Antibody neutralization would be a major way to prevent HIV infection and disease progression, but the complex relationship between host and pathogen makes tough to achieve this target through immunogens based on viral envelope proteins. Autoimmunity has been associated to bacterial and viral diseases, as a consequence of inflammatory response to pathogens; it may eventually lead to harm host cells and organs. However, autoimmune-like responses have also been observed in HIV-infected patients, raising many questions about their clinical significance. Recent studies have elucidated both similarities and differences between anti-self responses in HIV infection and autoimmune diseases, identifying new molecular players that might enhance immune protection to HIV and/or modulate the clinical progression of the established infection. This paper will present the current knowledge on auto-antibodies observed in HIV infection, their putative mechanisms of generation and their possible implications for immune therapy.

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Autoantibodies to the alpha/beta T-cell receptors in human immunodeficiency virus infection: dysregulation and mimicry.

Cited by 38 publications

References 30 publications

Antibodies and Genetically Engineered Related Molecules: Production and Purification

Antibodies and Genetically Engineered Related Molecules: Production and Purification

Evolutionary Stable Strategy: A Test for Theories of Retroviral Pathology which are Based upon the Concept of Molecular Mimicry

Is Autoimmunity a Component of Natural Immunity to HIV?

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