Autobiographical and episodic memory deficits in mild traumatic brain injury

Wammes, Jeffrey D.; Good, Tyler; Fernandes, Myra A.

doi:10.1016/j.bandc.2016.11.004

Cited by 68 publications

(48 citation statements)

References 90 publications

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“…Our finding on poorer episodic memory post-mTBI confirm the previous findings from MRI and CT studies with clinical TBI patients [31,51]. As shown in a recent study comparing over 80 young and older individuals with mTBI [52], declines in episodic memory may serve as an early indicator of post-mTBI premature aging among young adults like college students. Lower processing speed, which is one of the other main indices of brain aging along with declined executive function, was confirmed only when comparing the multiple injury group to the single injury group of our study.…”

Section: Discussionsupporting

confidence: 91%

The Long-Term Impact of Mild Traumatic Brain Injuries on Multiple Functional Outcomes and Epigenetics: A Pilot Study with College Students

Lee¹,

Lee²,

Black³

et al. 2020

Preprint

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People who suffer a mild traumatic brain injury (mTBI) have heterogeneous symptoms and disease trajectories, which make it difficult to precisely diagnose and assess complications long-term. Insufficient information is available regarding how to precisely diagnose and assess mTBI. This study identified and compared deficits in cognitive, psychosocial, visual functions, and balance performance between college students with and without histories of mTBI. Global DNA methylation ratio (5-mC%) in blood was also compared as a peripheral epigenetic marker. Twenty-five volunteers participated in this pilot study, including 11 mTBI cases (27.3% females; mean age of 28.7 years, SD=5.92) and 14 healthy controls (64.3% females; mean age of 22.0, SD=4.13). All the participants were assessed for cognitive (by NIH toolbox—executive function, memory, and processing speed), psychological (by PROMIS—depression, anxiety, and sleep disturbances), visual function (by King-Devick and binocular accommodative tests), postural balance performance (by a force plate), and blood 5-mC% (global methylation) levels. Students with mTBI reported significantly poorer episodic memory, severe anxiety, and more sleep disturbance problems. They also had higher blood 5-mC% level (all p’s<.05). No significant differences were found in visual function and postural balance. These findings validate changes in cognitive, psychosocial, and global DNA methylation long after mTBI.

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Section: Discussionsupporting

confidence: 91%

The Long-Term Impact of Mild Traumatic Brain Injuries on Multiple Functional Outcomes and Epigenetics: A Pilot Study with College Students

Lee¹,

Lee²,

Black³

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…Additionally, and similar to other studies [33][34][35][36], participants were excluded if they: Self-reported as a daily smoker [37,38] Self-reported being pregnant [39] Exercised within 5 hours of testing [40] Consumed caffeine within 3 hours of testing [41] Had a concussion or head trauma within the past 30 days [42] Took marijuana or other illegal drugs within the past 30 days [43] Were considered a daily alcohol user (>30 drinks/month for women; >60 drinks/month for men) [44]…”

Section: Participantsmentioning

confidence: 99%

Experimental Effects of Exercise on Forgetting

Ferguson¹,

Cantrelle²,

Loprinzi³

2018

obm icm

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Background: The present study evaluates the effects of selective directed forgetting (SDF) and directed forgetting (DF) on subsequent memory retrieval and investigate whether acute exercise can facilitate the effects of SDF. Methods: A four-arm (n=20 per group; N=80; M age =20 yrs), parallel-group, randomized controlled experiment was employed. The four groups included: 1) exercise plus SDF (Ex+SDF), 2) SDF only (SDF), 3) DF only (DF) and 4) R (remember) only (R). Participants viewed two separate word lists (list 1 and list 2; L1 and L2). Based on group assignment, participants were directed to either forget, selectively forget, or remember List 1. Outcome parameters included the number of words recalled from L1 and L2. Generally, participants directed to forget L1 tend to recall more words from L2. Thus, L1 represents forgetting whereas L2 represents the degree of memory enhancement. The exercise protocol involved a 15-minute bout of moderate-intensity treadmill exercise. Results: We observed a significant main effect for L1 Item-Type (F=18.0, P<.

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“…Consumed caffeine within 3 h of testing [24]. Had a concussion or head trauma within the past 30 days [29]. Took marijuana or other illegal drugs within the past 30 days [7].…”

Section: Participantsmentioning

confidence: 99%

Does Engaging in Acute Exercise Prior to Memory Encoding and During Memory Consolidation have an Additive Effect on Long-Term Memory Function?

Loprinzi

Chism

Marable

2019

J. of SCI. IN SPORT AND EXERCISE

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Previous work has demonstrated that acute exercise prior to memory encoding may enhance long-term memory. Similarly, other work demonstrates that acute exercise during the memory consolidation period may also enhance long-term memory function. However, no study has evaluated whether long-term memory is enhanced when an acute bout of exercise occurs during both of these time periods, when compared to just prior to memory encoding. A within-subject randomized controlled intervention was employed. On separate laboratory visits, participants completed two main protocols, including (1) exercise before memory encoding and (2) exercise before and after memory encoding. Long-term memory was assessed, via a word-list task, from a 20-min delay period and a 24-h delay period. We observed a significant main effect for time, F(8, 176) = 529.5, P < 0.001, η p 2 = 0.96, but no significant main effect for condition, F(1, 22) = 0.08, P = 0.77, η p 2 = 0.004, or time by condition interaction, F(8, 176) = 0.19, P = 0.99, η p 2 = 0.009. In conclusion, there was no difference in long-term memory function when comparing acute exercise only prior to memory encoding vs. acute exercise both before and immediately after memory encoding.

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Autobiographical and episodic memory deficits in mild traumatic brain injury

Cited by 68 publications

References 90 publications

The Long-Term Impact of Mild Traumatic Brain Injuries on Multiple Functional Outcomes and Epigenetics: A Pilot Study with College Students

The Long-Term Impact of Mild Traumatic Brain Injuries on Multiple Functional Outcomes and Epigenetics: A Pilot Study with College Students

Experimental Effects of Exercise on Forgetting

Does Engaging in Acute Exercise Prior to Memory Encoding and During Memory Consolidation have an Additive Effect on Long-Term Memory Function?

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