Autochthonous Crimean–Congo Hemorrhagic Fever in Spain

Negredo, Anabel; Calle-Prieto, Fernando de la; Palencia-Herrejón, Eduardo; Mora-Rillo, Marta; Astray‐Mochales, Jenaro; Sánchez-Seco, María Paz; López, E.; Menárguez, Javier; Fernández‐Cruz, Ana; Sánchez-Artola, Beatriz; Keough-Delgado, Elena; Arellano, Eva Ramírez de; Lasala, Fátima; Milla, Jakob; Fraile, Lorenzo; Gavín, María Ordobás; Gándara, Amalia Martinez de la; Perez, Lorenzo López; Diaz-Diaz, Domingo; López‐García, Martín; Delgado-Jimenez, Pilar; Martín-Quirós, Alejandro; Trigo, Elena; Figueira, Juan Carlos; Manzanares, Jesús Álvarez; Rodriguez-Baena, E; García-Comas, Luis; Rodríguez-Fraga, Olaia; García-Arenzana, Nicolás; Fernández-Díaz, Maria V.; Cornejo, Victor M.; Emmerich, Petra; Schmidt‐Chanasit, Jonas; Arribas, José Ramón

doi:10.1056/nejmoa1615162

Cited by 177 publications

(169 citation statements)

References 30 publications

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“…In 2016, CCHF was first described in Spain [44], which, despite evidence of CCHFV in nature based on tick surveillance studies [45], had no previous reports of autochthonous human cases. It was suggested that these reports represent a change in the geographic distribution of the main vector [44].…”

Section: Expansion By Infected Tick Introductionmentioning

confidence: 99%

“…It was suggested that these reports represent a change in the geographic distribution of the main vector [44]. In fact, data reveal that permanent populations of Hyalomma ticks have not changed in upwards of 50 years [46], though the presence of some species such as Hyalomma lusitanicum has been noted outside of their classic territories.…”

Section: Expansion By Infected Tick Introductionmentioning

confidence: 99%

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Crimean-Congo hemorrhagic fever and expansion from endemic regions

Spengler

Bergeron

Spiropoulou

2019

Current Opinion in Virology

108

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Crimean-Congo hemorrhagic fever (CCHF) is a virus-mediated hemorrhagic disease that occurs over a wide geographic region. In recent years, a variety of active and passive surveillance networks have improved our knowledge of areas with existing circulation of Crimean-Congo hemorrhagic fever virus (CCHFV), the etiologic agent of CCHF. These investigations aid in better defining the distribution of the virus. Expansion of a virus into new areas can occur through a variety of means, including introduction of infected humans, vectors, or animals. Here, these potential contributors to expansion of CCHFV into neighboring countries and geographically distant locations are reviewed, and the likelihood and possible implications of these events, based on known characteristics of the virus and its natural maintenance and transmission cycles are explored. Furthermore, this report discusses limitations in the currently described distribution of CCHFV, and the challenges in assessing viral circulation identified in a new region as geographic expansion of the virus.

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Section: Expansion By Infected Tick Introductionmentioning

confidence: 99%

Section: Expansion By Infected Tick Introductionmentioning

confidence: 99%

Crimean-Congo hemorrhagic fever and expansion from endemic regions

Spengler

Bergeron

Spiropoulou

2019

Current Opinion in Virology

108

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“…(Instituto de Salud Carlos III, Majadahonda, Spain) presented two human cases that occurred in Spain in 2016, the first in this country (Negredo et al, 2017). The viruses isolated from these patients are included in Africa-3 lineage, the same lineage as virus found in local ticks.…”

Section: Meeting Sessionsmentioning

confidence: 99%

“…(Instituto de Salud Carlos III, Majadahonda, Spain) speaking on behalf of Marta Mora-Rillo (Hospital Universitario La Paz, Madrid, Spain), presented two cases of CCHF in Spain (Negredo et al, 2017). The virus was first detected in Spain in ticks in 2010, but human infection was not observed until 2016, when a 60-year-old man who noted a tick bite while hiking was hospitalized with fever, thrombocytopenia, and coagulopathy, leading to fatal hepatic failure.…”

Section: Meeting Sessionsmentioning

confidence: 99%

Second International Conference on Crimean-Congo Hemorrhagic Fever

et al. 2018

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The Second International Conference on Crimean-Congo Hemorrhagic Fever (CCHF) was held in Thessaloniki, Greece, from September 10-13, 2017, and brought together international public health professionals, clinicians, ecologists, and basic laboratory researchers. Nearly 100 participants, representing 24 countries and the World Health Organization (WHO), were in attendance. Meeting sessions covered the epidemiology of CCHF in humans; ticks and virus-tick interactions; wild and domestic animal hosts; molecular virology; taxonomic classification; pathogenesis and animal models; clinical aspects and diagnosis; clinical management and clinical trials; and disease prevention in humans. The concluding session focused on recent WHO recommendations for public health measures and future research. This report summarizes lectures by the invited speakers and highlights advances in the field.

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“…Importantly, many – if not most – of the studies did not report on the demographic characteristics of the study participants and the impact upon underserved populations. The “digital divide” [9], the differential access to the internet and related technologies based on economic, geographic, and social factors, is an enormous barrier to the use of digital sensors and telehealth generally [10, 11]. One important study [5] in southern California that sought to empower individuals with uncontrolled hypertension and diabetes by using digital pills to track adherence, wearable sensors, and a mobile application enrolled 109 participants, of whom 46% were Hispanic, 57% had an income of less than USD 20,000, and 52% had a high school education or less.…”

Section: Overviewmentioning

confidence: 99%

The Best Digital Biomarkers Papers of 2017

2018

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The use and evaluation of digital biomarkers, objective and quantifiable measures of biology, and health collected through digital devices is growing rapidly. To highlight some of the most promising work in the field, we have compiled a list of the top digital biomarkers papers from the past year. Eligible papers reported on original research that evaluated a digital sensor (e.g., smartphone, wearable sensor, implantable device) in humans and was published in a peer-reviewed journal in 2017. Nominations were solicited from the editorial board of Digital Biomarkers and supplemented by papers the editorial team identified from Web of Science, Google Scholar, and PubMed. The editorial board then selected up to ten papers to be recognized among 28 nominations. Here, we present all of the nominated papers and profile the eight that received the most votes. The top eight papers evaluated 1,290 individuals with digital pills, smartwatches, wearable devices, and electronic inhalers in disease states ranging from dementia to diabetes and from Parkinson disease to pain.

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Autochthonous Crimean–Congo Hemorrhagic Fever in Spain

Cited by 177 publications

References 30 publications

Crimean-Congo hemorrhagic fever and expansion from endemic regions

Crimean-Congo hemorrhagic fever and expansion from endemic regions

Second International Conference on Crimean-Congo Hemorrhagic Fever

The Best Digital Biomarkers Papers of 2017

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