Autoerythrocyte Sensitization Syndrome with Thrombocytosis

Gomi, Hiroko; Miura, Takao

doi:10.1159/000247125

Cited by 17 publications

(12 citation statements)

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“…25 In one case report, busulfan (myelosan) was effective in a patient with GDS, accompanied by thrombocytosis. 54 In another case, promethasine was more helpful in relieving pain than tramadol. 31 In some patients, psychotropic medications were successfully prescribed according to type and severity of psychopathological or personality disorders.…”

Section: Treatmentmentioning

confidence: 97%

“…It was shown that these patients can undergo surgical operations without bleeding complications, although operations normally are contraindicated in persons with this condition 53 . There are only sporadic reports about comorbidity of GDS with thrombocytosis, 54 defective thrombocyte aggregation, 38 increase of activated partial thromboplastin time as a result of factor ÕII deficit, 30 idiopathic thrombocytopenic purpura, 55 and circulating fibrinolytic factor 56 …”

Section: Aetiology and Pathogenesismentioning

confidence: 99%

“…Glucocorticoids, cytostatic drugs, hormonal contraceptives, antibiotics, quinolones are not effective; their effect is similar to placebo 25 . In one case report, busulfan (myelosan) was effective in a patient with GDS, accompanied by thrombocytosis 54 . In another case, promethasine was more helpful in relieving pain than tramadol 31 .…”

Section: Treatmentmentioning

confidence: 99%

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Autoerythrocyte sensitization syndrome (Gardner-Diamond syndrome): review of the literature**

Миченко

et al. 2009

Journal of the European Academy of Dermatology and Venereology

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A review of the literature concerning psychogenic purpura is presented. The diagnosis is usually based on typical anamnestic data, clinical presentation (painful inflammatory skin lesions, which progressed to ecchymoses during the next 24 h) and positive diagnostic tests with intracutaneous injections of 80% solution of washed autologous erythrocytes. No pathological findings of blood coagulation parameters are usually detected. Histopathological evaluations of lesional biopsies revealed non-specific changes. Taking into account the high frequency of psychic disorders and stress dependence of skin symptoms, therapy with psychotropic drugs (according to indications) and psychotherapy are pathogenetically grounded methods of treatment in psychogenic purpura, and should be provided together with symptomatic therapy.

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Section: Treatmentmentioning

confidence: 97%

Section: Aetiology and Pathogenesismentioning

confidence: 99%

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Autoerythrocyte sensitization syndrome (Gardner-Diamond syndrome): review of the literature**

Миченко

et al. 2009

Journal of the European Academy of Dermatology and Venereology

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“…Barba et al (11) reported a functional platelet defect in one patient with AES syndrome. A case of AES syndrome associated with thrombocytosis was reported; the patient was treated with busulfan with delayed improvement of the ecchymosis over 2 yr of follow-up (12). Di Grande reported a case of AES syndrome with platelet factor-III de®ciency (13).…”

Section: Discussionmentioning

confidence: 99%

Autoerythrocyte sensitization(Gardner–Diamond) syndrome

Uthman¹,

Moukarbel

Salman

et al. 2000

European J of Haematology

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We describe the clinical presentation and course of a patient with autoerythrocyte sensitization (Gardner-Diamond) syndrome, and review the literature for similar cases. A 37-yr-old female presented with recurrent episodes of painful ecchymotic bruising over the anterior aspect of both thighs. These episodes were precipitated by emotional stress. The diagnosis was confirmed by induction of similar lesions by intradermal injection of the patient's own washed red blood cells and hemoglobin. The lesions did not recur for 6 months after the cause of her emotional stress was relieved. Autoerythrocyte sensitization (Gardner-Diamond) syndrome should be considered in the differential diagnosis of purpura, especially in patients with psychiatric problems.

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“…GDS hastalarında trombosit fonksiyonlarında defekt ve trombositoz gibi hematolojik bozukluklarla, sistemik lupus eritematozus gibi immunolojik bozukluklar da bildirilmiştir (1,8,14). Olgumuzda herhangi bir hematolojik veya immunolojik bozukluk saptanmadı.…”

Section: Olguunclassified

Gardner-Diamond syndrome: case report

Öztürk¹,

Akman²,

Sayar³

2012

Gaziantep Med J

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ÖzetGardner-Diamond Sendromu (otoeritrosit sensitizasyon sendromu) genellikle genç kadınlarda tekrarlayan, ağrılı ekimotik plaklarla karakterize bir hastalıktır. Ekimozlar, özellikle emosyonel stres veya hafif travma sonrasında spontan olarak ortaya çıkar. En sık tutulan bölgeler ekstremitelerdir. Burada Gardner-Diamond Sendromu ile birlikte yaygın anksiyete ve depresyon tanısı alan 25 yaşındaki olgu sunularak, nadir görülen bu hastalığın psikiyatrik bozukluklarla bağlantısına dikkat çekildi ve literatür gözden geçirildi. Anahtar kelimeler: Anksiyete; Depresyon; Gardner-Diamond Abstract Gardner-Diamond syndrome is characterized with recurrent, painful, ecchymotic plaques usually seen in young women. Ecchymosis spontaneously occurs after emotional stress and mild trauma. The lesions mostly seen in extremities. In this case, 25 year old patient diagnosed with Gardner-Diamond syndrome with depression and anxiety is presented. Attention has been drawn to this disease in connection with psychiatric disorders and also the literature was reviewed.

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Autoerythrocyte Sensitization Syndrome with Thrombocytosis

Cited by 17 publications

References 1 publication

Autoerythrocyte sensitization syndrome (Gardner-Diamond syndrome): review of the literature**

Autoerythrocyte sensitization syndrome (Gardner-Diamond syndrome): review of the literature**

Autoerythrocyte sensitization(Gardner–Diamond) syndrome

Gardner-Diamond syndrome: case report

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