Autogenous Bacterial Vaccines in Treatment of Asthma

Disconnection of man and the soil: Reason for the asthma and atopy epidemic?

“…61 Bacterial extracts obtained mainly from species associated with upper respiratory tract and urinary tract infections administered subcutaneously were earlier used for such purposes but are not in use today because several double-blind studies showed no efficacy in asthma, possibly because of overly low concentrations of bacterial material in these extracts, nonoptimal route of administration, and overly long intervals between the doses (1 week or longer). No studies on the preventive effect of oral bacterial extracts are available.…”

Allergic asthma in childhood.

“…Wellcontrolled investigations have failed to support the empirical idea of treating asthma with bacterial extracts, a placebo having proved equally effective (Aas et al, 1963;Fontana et al, 1965;Frankland, Hughes, and Gorrill, 1955;Helander, 1959;Johnstone, 1959;Weil, 1960), except in one study (Barr et al, 1965).…”

Renaissance of the hygiene hypothesis

“…Therapeutically, various forms of microbial immunotherapy to treat asthma have come in and out of favor, with neither a strong burden of evidence nor a refined understanding to support their use (eg, respiratory bacterial vaccines 35 and Endo-dust allergen extracts 36 ). The current renaissance has brought novel microbe-derived therapeutic interventions a long way from this, with extensive preclinical studies of the protective or therapeutic influence of various microbial exposures, ranging from vaccines to TLR ligand derivatives and conjugates to microbial extracts.…”