19PFifteen untreated patients with a presumptive diagnosis of hypertension were studied for periods up to 48 h with the Oxford continuous intra-arterial pressure recorder. In each case a denned protocol of rest and exercise (using an Elema bicycle ergometer) was followed before the patients left the hospital. Blood pressure was characterized in each patient by a 6-hourly daytime mean systolic and diastolic measurement, and by peak responses to increasing levels of exercise. The 6-hourly mean pressures were compared with the indirect clinic recordings, and a weak correlation was found. A stronger correlation was found on comparing the 6-hourly means with the response to maximal exercise. The four patients who showed electrocardiographic evidence of severe left ventricular hypertrophy responded to exercise in an identical fashion to the main group. It is suggested that blood pressure response to exercise may be a better indicator of raised blood pressure than a casual resting clinic recording in borderline subjects. THE CELLULAR DEFECT IN IgA DEFICIENCY

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