Local Production of IgG, IgA and IgE Antibody to Pollen Antigens in Patients with Hay Fever

Abstract

19PFifteen untreated patients with a presumptive diagnosis of hypertension were studied for periods up to 48 h with the Oxford continuous intra-arterial pressure recorder. In each case a denned protocol of rest and exercise (using an Elema bicycle ergometer) was followed before the patients left the hospital. Blood pressure was characterized in each patient by a 6-hourly daytime mean systolic and diastolic measurement, and by peak responses to increasing levels of exercise. The 6-hourly mean pressures were compared with the indirect clinic recordings, and a weak correlation was found. A stronger correlation was found on comparing the 6-hourly means with the response to maximal exercise. The four patients who showed electrocardiographic evidence of severe left ventricular hypertrophy responded to exercise in an identical fashion to the main group. It is suggested that blood pressure response to exercise may be a better indicator of raised blood pressure than a casual resting clinic recording in borderline subjects. THE CELLULAR DEFECT IN IgA DEFICIENCY

A Quantitative Analysis of Cedar Pollen‐Specific Immunoglobulins in Nasal Lavage Supported the Local Production of Specific IgE, Not of Specific IgG

“…The mean proportion of JCP-specific IgE was approximately 100-fold higher than IgA and IgG (Table 1), in both the NLF and serum, and was quite consistent with previous studies with serum (19) or explant culture (20). Such a great difference among immunoglobulin classes could be rationalized by hypothesizing that certain restricted tissues, including the nasal mucosa, are dominantly responsible for total IgE production in modern environments.…”

“…These results of specific IgE and IgG proportion were in good agreement with a study that mucosal explant from hay fever patients could produce IgE but not IgG antibody, in vitro (20). On the other hand, the data about IgG contrasts with a previous report that the specific proportion of IgG is higher in nasal discharge than in serum (19).…”

“…Among the subjects, the degree of passive translocation into NLF apparently fluctuated to a large extent (undetectable to 16% for IgE, 0.003% to 5.1% for IgG), so the absolute concentrations of IgE and IgG could not be quantitatively compared. Instead, the relative specific antibody proportions in total IgE and IgG deserved quantitative comparisons in a similar way as a previous study (7,19). The specific antibody amounts were estimated depending on the standard curves for total immunoglobulins of each class.…”

The role of the T follicular helper cells in allergic disease

“…32 In humans, IgG and IgA are produced locally as evidenced by the higher proportion of specific antibody to total immunoglobulin in nasal secretions. 33 Likewise, evidence for local IgE production can be found in tears. 34 Patients who are allergic to bee venom may remain sensitive decades after their last exposure.…”

B-lymphocyte lineage cells and the respiratory system

“…[215][216][217] Several studies have shown that levels of aeroallergen-specific IgE are much higher in the airways than in the serum when normalized to total IgE or albumin. [216][217][218][219][220][221][222] It is not uncommon for individuals with allergic rhinitis or chronic rhinosinusitis (CRS) to manifest antigen-specific IgE in nasal secretions or nasal tissue with no apparent specific IgE in the serum for the same antigen, and documented cases exist in which nasal antigen challenge responses are elicited in individuals that lack skin test sensitivity. 215,217,218,220 A survey study found that 19% of patients with rhinitis and polyposis had specific IgE in the nose but not the serum.…”