Autoimmune amelogenesis imperfecta in patients with APS-1 and coeliac disease

Gruper, Yael; Wolff, Anette S. B.; Glanz, Liad; Spoutil, Frantisek; Marthinussen, Mihaela Cuida; Osickova, Adriana; Herzig, Yonatan; Goldfarb, Yael; Aranaz-Novaliches, Goretti; Dobeš, Jan; Kadouri, Noam; Ben-Nun, Osher; Binyamin, Amit; Lavi, Bar; Givony, Tal; Khalaila, Razi; Gome, Tom; Wald, Tomáš; Mrazkova, Blanka; Sochen, Carmel; Besnard, Marine; Ben-Dor, Shifra; Feldmesser, Ester; Orlova, Elisaveta M.; Hegedűs, Csaba; Lampé, István; Papp, Tamás; Felszeghy, Szabolcs; Sedlacek, Radislav; Davidovich, Esti; Tal, Noa; Shouval, Dror S.; Shamir, Raanan; Guillonneau, Carole; Szondy, Zsuzsa; Lundin, Knut E. A.; Osicka, Radim; Prochazka, Jan; Husebye, Eystein S.; Abramson, Jakub

doi:10.1038/s41586-023-06776-0

Nature

2023

DOI: 10.1038/s41586-023-06776-0

|View full text |Cite

Autoimmune amelogenesis imperfecta in patients with APS-1 and coeliac disease

Yael Gruper,

Anette S. B. Wolff,

Liad Glanz

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article5

Relationship

Self Cite0

Independent5

Authors

Journals

Cited by 7 publications

References 75 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Advancing dentin remineralization: Exploring amorphous calcium phosphate and its stabilizers in biomimetic approaches

Yang,

Zheng,

Zhao

et al. 2024

Dental Materials

View full text Add to dashboard Cite

Advancing dentin remineralization: Exploring amorphous calcium phosphate and its stabilizers in biomimetic approaches

Yang,

Zheng,

Zhao

et al. 2024

Dental Materials

View full text Add to dashboard Cite

The intricacies of tooth enamel: Embryonic origin, development and human genetics

Duverger,

Lee

2024

Journal of Structural Biology

View full text Add to dashboard Cite

Where AIRE we now? Where AIRE we going?

Bez,

Ceraudo,

Vianello

et al. 2024

Current Opinion in Allergy &Amp; Clinical Immunology

View full text Add to dashboard Cite

Purpose of review The purpose of the review is to describe the most recent advancement in understanding of the pivotal role of autoimmune regulator (AIRE) gene expression in central and peripheral tolerance, and the implications of its impairment in the genetic and pathogenesis of autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) manifestations with insight into possible treatment options. Recent findings AIRE gene expression has an important role of central and peripheral tolerance. Different AIRE gene mutations cause APECED, whereas polymorphisms and some variants may be implicated in development of other more frequently autoimmune diseases. Impaired negative T cell selection, reduction of T regulatory function, altered germinal center response, activated B cells and production of autoantibodies explain the development of autoimmunity in APECED. Recent data suggest that an excessive interferon-γ response may be the primer driver of the associated organ damage. Therefore, Janus kinase (JAK)-inhibitors may be promising therapies for treatment of broad spectrum of manifestations. Summary AIRE has a pivotal role in immune tolerance. Disruption of this delicate equilibrium results in complex immune perturbation, ranging from severe autoimmunity, like APECED, to more common organ-specific disorders. Therefore, a deeper understanding of the correlation between AIRE function and clinical phenotype is warranted given the potential translational implication in clinical practice.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Autoimmune amelogenesis imperfecta in patients with APS-1 and coeliac disease

Cited by 7 publications

References 75 publications

Advancing dentin remineralization: Exploring amorphous calcium phosphate and its stabilizers in biomimetic approaches

Advancing dentin remineralization: Exploring amorphous calcium phosphate and its stabilizers in biomimetic approaches

The intricacies of tooth enamel: Embryonic origin, development and human genetics

Where AIRE we now? Where AIRE we going?

Contact Info

Product

Resources

About