Autoimmune diseases in adults with atopic dermatitis

Andersen, Y.M.F.; Egeberg, Alexander; Gislason, Gunnar; Skov, Lone; Thyssen, Jacob P.

doi:10.1016/j.jaad.2016.08.047

Cited by 117 publications

(132 citation statements)

References 46 publications

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“…(8, 9) A more recent large cross-sectional study based on healthcare claims data from Denmark found even stronger associations between adult AD and AA (Odds Ratio (OR) 26.31, 95% confidence interval (CI) 14.48–47.80) and vitiligo (OR 17.98, 95% CI 7.70–42.01). (10) We aimed to conduct the first prospective study examining the association of incident AA and vitiligo with AD in the Nurses’ Health Study 2 (NHS2).…”

Section: Introductionmentioning

confidence: 99%

Incident alopecia areata and vitiligo in adult women with atopic dermatitis: Nurses’ Health Study 2

Drucker

Thompson

et al. 2017

Allergy

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We aimed to determine the risk of AA and vitiligo associated with AD in a large cohort of US women, the Nurses’ Health Study 2. We used logistic regression to calculate age- and multivariate-adjusted odds ratios to determine the risk of incident AA and vitiligo associated with AD diagnosed in or before 2009. A total of 87,406 and 87,447 participants were included in the AA and vitiligo analyses, respectively. A history of AD in 2009 was reported in 11% of participants. There were 147 incident cases of AA and 98 incident cases of vitiligo over 2 years of follow-up. AD was associated with increased risk of developing AA (OR 1.80, 95% CI 1.18–2.76) and vitiligo (OR 2.14, 95% CI 1.29–3.54) in multivariate models. In this study of US women, AD was associated with increased risk of incident vitiligo and AA in adulthood.

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Section: Introductionmentioning

confidence: 99%

Incident alopecia areata and vitiligo in adult women with atopic dermatitis: Nurses’ Health Study 2

Drucker

Thompson

et al. 2017

Allergy

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“…Recently, dupilumab, a human monoclonal antibody targeting the α‐subunit of the interleukin (IL)‐4 receptor, shared by the Th2‐related cytokines IL‐4 and IL‐13, showed good results in AD, becoming the first biologic available for disease management . AD is commonly associated with other chronic inflammatory conditions, including alopecia areata (AA), a chronic inflammatory nonscarring type of hair loss . Current therapies for AA are rather limited, typically involving topical, intralesional or systemic steroids, leading to poor clinical response with numerous side‐effects and significant burden.…”

mentioning

confidence: 99%

Dual efficacy of dupilumab in a patient with concomitant atopic dermatitis and alopecia areata

Darrigade

Legrand²,

Andreu³

et al. 2018

Br J Dermatol

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“…Associations between digestive autoimmune disease, in particular IBD, and AD have been noted consistently, with few exceptions . However, associations between parental IBD and AD development in their children have only be studied once previously; an Israeli study showed an inverse association between maternal IBD and AD in her children, although this study did suffer from some methodological problems including imprecise information regarding selection of controls, failure to report criteria for AD diagnosis and no adjustment for multiple significance testing .…”

Section: Discussionmentioning

confidence: 92%

“…Autoimmune skin diseases such as vitiligo, alopecia areata and chronic urticaria have previously shown to be associated with AD. In contrast, it is thought that psoriasis and AD are inversely associated, likely a result of their opposing immune and cytokine pathways .…”

Section: Discussionmentioning

confidence: 99%

Association between parental autoimmune disease and atopic dermatitis in their offspring: a matched case–control study

Hamann

Egeberg

Silverberg

et al. 2019

Acad Dermatol Venereol

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Background Atopic dermatitis (AD) is associated with many autoimmune diseases, in part due to overlapping genetic risk loci. While parental atopic disease is an important risk for AD in the offspring, little is known on the putative associations between parental autoimmune disease and AD in their children. Materials and methods All children born between 1996 and 2011 who received a diagnosis of AD in the hospital system before their fifth birthday were matched 1 : 10 with children from the general population. Maternal and paternal autoimmune diseases were assessed using registry‐based data. Conditional logistic regression was performed on the relationships between parental autoimmune diseases and AD in their children. Results A total of 8589 children with AD were matched with controls. One or more autoimmune disease was identified in 5.89% (506/8589) of mothers to AD children and 3.67% (315/8589) of fathers to AD children compared to 4.85% (4163/85 890) and 3.28% (2816/85 890) in parents of control children. Maternal autoimmune disease but not paternal autoimmune disease was associated with AD in the offspring (odds ratio [OR] 1.20 [95% confidence interval (CI) 1.20–1.32] and OR 1.08 [0.96–1.22], respectively), Two or more maternal autoimmune diseases, maternal dermatologic autoimmune disease and maternal digestive autoimmune disease were all also associated with AD development in her children (1.96 [95% CI 1.36–2.84], OR 1.60 [95% CI 1.24–2.07] and OR 1.24 [95% CI 1.06–1.45], respectively). Conclusions The risk of AD is influenced by many factors including atopy status and filaggrin gene mutations. In this matched case–control study, maternal autoimmune disease was associated with AD diagnosis in the offspring. Maternal dermatologic and digestive autoimmune diseases were most closely associated with subsequent AD diagnosis in the offspring.

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Autoimmune diseases in adults with atopic dermatitis

Cited by 117 publications

References 46 publications

Incident alopecia areata and vitiligo in adult women with atopic dermatitis: Nurses’ Health Study 2

Incident alopecia areata and vitiligo in adult women with atopic dermatitis: Nurses’ Health Study 2

Dual efficacy of dupilumab in a patient with concomitant atopic dermatitis and alopecia areata

Association between parental autoimmune disease and atopic dermatitis in their offspring: a matched case–control study

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