2007
DOI: 10.1177/1352458506071333
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Autoimmune hemolytic anemia during interferon-beta-I b treatment for multiple sclerosis

Abstract: A 31-year-old patient with multiple sclerosis (MS), treated with interferon beta-1b (IFNB-1b) for two years, presented with fatigue and dizziness. Coombs' positive autoimmune hemolytic anemia (AIHA) was found. Other potential etiologies of AIHA were ruled out. An association with IFNB-1b was highly suspected. Interferon therapy was discontinued and prednisone therapy instituted. There was resolution of the hemolytic anemia, and prednisone therapy was tapered gradually. To the best of our knowledge, there is no… Show more

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Cited by 15 publications
(15 citation statements)
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“…One negative effect of chronic high levels of IFN-I seems to be the inhibition of red blood cell production (38). Indeed, we observe a mild anemia in MDA5 Tg that fits the pattern of what has been described as anemia of chronic disease and that it somewhat mimics the anemia detected in patients that receive repeated IFNβ treatments (39, 40). Another issue that appears to result from this high level of ISGs is the fact that adaptive immune priming in response to a virus is impaired in MDA5 Tg animals.…”
Section: Discussionsupporting
confidence: 84%
“…One negative effect of chronic high levels of IFN-I seems to be the inhibition of red blood cell production (38). Indeed, we observe a mild anemia in MDA5 Tg that fits the pattern of what has been described as anemia of chronic disease and that it somewhat mimics the anemia detected in patients that receive repeated IFNβ treatments (39, 40). Another issue that appears to result from this high level of ISGs is the fact that adaptive immune priming in response to a virus is impaired in MDA5 Tg animals.…”
Section: Discussionsupporting
confidence: 84%
“…The described cases similar to the literature review suggest a possible causative relation between MS and anaemic syndrome (1,5,6,7,10). The analysis could be useful for clarifying the nature of comorbidity of these diseases.…”
Section: Conclusion and Discussionsupporting
confidence: 80%
“…An association of MS with different anaemic syndromes has been reported (1,3,5,8,10,12). Most common are states of B12 deficiency and pernicious anaemia, occurring before or during the development of MS (2, 13).…”
mentioning
confidence: 96%
“…Despite the well-known adverse event of disease-modifying therapies on inducing anemia [6,7,8,9,10,11,12,13,14], there was no significant difference in anemia rate in the different treatment groups. Anemia percentages ranged from 12% in patients treated with Copaxone up to 27.3% in those treated with Tysabri, with a mean of 17.8% in the untreated patients similar to the overall anemia rate in MS patients (18.7%).…”
Section: Discussionmentioning
confidence: 95%
“…Among the various conditions suspected to be associated with MS, vitamin B12 deficiency and pernicious anemia have been extensively studied, confirming essentially their comorbidity [2,3,4,5]. Several case reports regarding drug-related hemolytic anemia in MS patients have also been described in the literature [6,7,8,9,10,11,12,13,14]. Conversely, there is little knowledge on the association between MS and other types of anemia including those related to iron deficiency [15], chronic disorders, and Mediterranean anemia despite a high prevalence of the thalassemia trait in the Sardinian population.…”
Section: Introductionmentioning
confidence: 99%