Autoimmune hemolytic anemia in children during 2004–2014 in the Department of Pediatrics, Hematology and Oncology, Warsaw Medical University

Wołowiec, Magdalena; Adamowicz-Salach, Anna; Gołębiowska-Staroszczyk, Sydonia; Demkow, Urszula; Skrzypczak-Pamięta, Małgorzata; Michalewska, Bogumiła; Matysiak, Michał

doi:10.1016/j.poamed.2015.04.012

Cited by 2 publications

(5 citation statements)

References 20 publications

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“…Forty cohort studies (36 retrospective, 3 prospective, and 1 ambispective) and three case–control studies (two retrospective and one prospective) were included 5–7,14–53 . No randomized controlled trials were identified.…”

Section: Resultsmentioning

confidence: 99%

“…Twenty‐one studies (49%) reported AIHA subtypes within their population 5–7,17,18,21,23,24,27,32,34,36,37,39,41,43,46,48,50,52,53 . Four studies (9%) focused solely on warm AIHA, 5,36,48,53 while the remaining studies included patients with mixed AIHA, paroxysmal cold hemoglobinuria (PCH), and cold agglutinin disease (CAD).…”

Section: Resultsmentioning

confidence: 99%

“…Aside from those 7 studies, patients with ES were included in 23 (53%) studies, 5–7,14,16,17,20–22,25,26,28,29,32,34,36,39,41,42,46,48,50,51 although not all studies explicitly referred to multilineage autoimmune cytopenias as ES. Five (12%) studies did not disclose AIHA secondary to any IEI, autoimmune conditions, or transplant recipients 18,31,37,41,53 …”

Section: Resultsmentioning

confidence: 99%

“…Common second‐line therapies included rituximab in 17 studies (40%), 6,14,15,17,22,25,28,32,34,37–39,44,47,48,50,52 cyclosporine in 13 studies (30%), 5,15,27,28,32,34,36–38,41,44,47,48 IVIG in 13 studies (30%), 14,15,17,22,25,27,31,32,34,36,39,47,50 and/or combinations of these therapies. Of the three studies that did not report treatments, one focused on the reporting results of DAT testing, 18 another only looked at diagnostic testing, 42 and another analyzed the delay seen in diagnosing ES in those with underlying autoimmune conditions 33 …”

Section: Resultsmentioning

confidence: 99%

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Childhood autoimmune hemolytic anemia: A scoping review

Zhang,

Charland,

O'Hearn

et al. 2024

European J of Haematology

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Background and objectiveAutoimmune hemolytic anemia (AIHA) is a rare but important cause of morbidity in pediatric hematology patients. Given its rarity, there is little high‐quality evidence on which to base the investigation and management of pediatric AIHA. This scoping review aims to summarize the current evidence and highlight key gaps to inform future studies.MethodsThis review searched MEDLINE and the Cochrane CENTRAL Trials Register from 2000 to November 03, 2023. Experimental and observational studies reporting AIHA diagnostic criteria, laboratory workup, or treatment/management in populations with at least 20% of patients ≤18 years were included.ResultsForty‐three studies were included, with no randomized controlled trials identified. AIHA diagnostic criteria, diagnostic tests, and treatments were highly variable. First‐line treatment approaches include corticosteroids, intravenous immunoglobulin, or both. Approaches to AIHA resistance to first‐line therapy were widely variable between studies, but most commonly included rituximab and/or cyclosporine.ConclusionsWe identify a heterogenous group of observational studies into this complex, immune‐mediated disorder. Standardized definitions and classifications are needed to guide collaborative efforts needed to study this rare disease. The work done by the CEREVANCE group provides an important paradigm for future studies.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Childhood autoimmune hemolytic anemia: A scoping review

Zhang,

Charland,

O'Hearn

et al. 2024

European J of Haematology

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show abstract

“…Cold reactive auto antibodies are responsible for the less frequent form of the disease, also known as primary or cold agglutinin syndrome (CAS). A small subset of cases may have both warm and cold antibodies known as mixed AIHA [4].…”

Section: Introductionmentioning

confidence: 99%

Autoimmune Haemolytic Anaemia as Initial and Only Presentation of Systemic Lupus Erythematosus: A Case Report

Ikejiaku,

Ezerioha,

Nwaoha

et al. 2023

IJTDH

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Autoimmune haemolytic anaemia (AIHA) is an acquired disorder resulting in the presence of antibodies against red blood cell antigens which leads to intravascular haemolysis. It can occur as the initial and sometimes the only presenting feature of Systemic Lupus Erythematosus (SLE). In this report, we describe the diagnostic evaluation and ongoing management of a 13-year-old female with AIHA as the first clinical feature of SLE. She presented with paleness of the body and yellowish discoloration of the eyes. Initial examination showed severe pallor with moderate jaundice. Investigations revealed severe anaemia with slightly elevated reticulocyte count and positive direct coombs test(DCT). Peripheral blood film showed microcytic, hypochromic anaemia. Bone marrow aspiration showed a hypocellular marrow for the age of the child. Immunological screening results were positive for antinuclear antibody (ANA) and anti-double stranded DNA (Anti-ds DNA). Patient is currently on Prednisolone, hydroxychloroquine and mycophenolate mofetil(MMF). The diagnosis of SLE with AIHA requires a good history, physical examination, high index of suspicion and extensive investigations. Management entails multidisciplinary approach, supportive care, initiation of treatment with steroids and immunosuppressive drugs if necessary to minimize morbidity and mortality.

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Autoimmune hemolytic anemia in children during 2004–2014 in the Department of Pediatrics, Hematology and Oncology, Warsaw Medical University

Cited by 2 publications

References 20 publications

Childhood autoimmune hemolytic anemia: A scoping review

Childhood autoimmune hemolytic anemia: A scoping review

Autoimmune Haemolytic Anaemia as Initial and Only Presentation of Systemic Lupus Erythematosus: A Case Report

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