Autoimmune liver diseases in systemic rheumatic diseases

Wang, Chrong‐Reen; Tsai, Hung‐Wen

doi:10.3748/wjg.v28.i23.2527

Cited by 31 publications

(19 citation statements)

References 186 publications

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“…In the literature-review-based cohort, the most common associated disease was psoriasis, and, as occurs for IBD, primary sclerosing cholangitis was the most common hepatobiliary complication [ 88 , 89 ].…”

Section: Discussionmentioning

confidence: 99%

Chronic Nonbacterial Osteomyelitis and Inflammatory Bowel Disease: A Literature Review-Based Cohort

et al. 2023

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Background: Chronic nonbacterial osteomyelitis (CNO) is a rare autoinflammatory bone disorder that mainly involves children and adolescents. The association with other inflammatory disorders, such as inflammatory bowel disease (IBD), psoriasis, and arthritis, has been reported in the literature. In particular, the relationship between bone and intestinal inflammation is still poorly understood. For this purpose, our review aims to describe the cases reported in the literature concerning this association and to compare them with data from our single-center cohort of patients. Methods: We conducted a literature review of published cases of CNO associated with IBD. Eligible articles were identified through a Medline search in the PubMed database until December 2022. We retrospectively reviewed medical records of patients with CNO referred to G. Pini Hospital and compared them with the literature-review-based cohort. Results: Fifty-seven patients with a defined diagnosis of CNO and associated IBD were described in the literature (female 55%). The median age of onset of the disease (CNO or IBD) was 11 years. In 32/53 (60%), a diagnosis of Crohn’s disease (CD) was made, while 18 (34%) patients were classified as suffering from ulcerative colitis (UC) and 3 (6%) from undifferentiated IBD. The diagnosis of CNO preceded the diagnosis of IBD in 59% of cases; while in 24%, IBD anticipated CNO; and in 17%, the two conditions appeared simultaneously. The median time between the two events was 24 months. In our Italian cohort (n = 23 patients), no diagnosis of IBD was made. No significant differences were found when comparing clinical and demographical characteristics of the Italian vs. review-based cohort, except for a significant involvement of rachis in the Italian group. Conclusions: The correlation between autoinflammatory bone disease and intestinal inflammation should be further investigated. It is essential to promote awareness among pediatric rheumatologists and gastroenterologists about this possible association to facilitate the diagnosis and better optimize treatment.

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Section: Discussionmentioning

confidence: 99%

Chronic Nonbacterial Osteomyelitis and Inflammatory Bowel Disease: A Literature Review-Based Cohort

et al. 2023

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“…Liver damage in RA is con rmed in clinical practice and TNF-Tg mice. However, the early symptoms of liver damage in RA is often di cult to determine [29]. Moreover, the proteinuria levels, active urine sediment and clinical signs also can not accurately predict renal histology in RA [30].…”

Section: Discussionmentioning

confidence: 99%

Hepatorenal pathologies in TNF-transgenic mouse model of rheumatoid arthritis are alleviated by anti-TNF treatment

Wang

Chen

et al. 2023

Preprint

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Objective To examine and quantify liver and kidney lesions and their response to anti-TNF therapy in TNF-Tg mouse model of rheumatoid arthritis. Methods Female TNF-Tg (Tg3647) mice were used as the animal model of chronic rheumatoid arthritis. Ultrasound, immunofluorescence and histology staining, serology test and real-time PCR were used to examine the pathological changes in liver and kidney. Results TNF-Tg mice showed a significant decrease in body weight and a dramatic increase in the volumes of gallbladder, knee cavity, and popliteal lymph nodes. Liver and kidney of TNF-Tg mice were demonstrated increased chronic inflammation, accumulation of immune cells, fibrosis and senescence, compared to the wide-type (WT) mice. Moreover, up-regulation of inflammatory factors and impaired normal function were also observed in the liver and kidney of TNF-Tg mice. The inflammation infiltration, fibrosis and senescence in liver and kidney of female TNF-Tg mice were improved after anti-TNF treatment, and better treatment effects were achieved at 8 weeks of intervention. Conclusions We found that TNF drives the development of liver and kidney pathology in female TNF-Tg mice, and there are limitations in the loss of utility of Anti-TNF for prolonged treatment of RA-associated hepatic and renal injury. This study provided a reliable and high clinically relevant animal model for the further study to explore the molecular mechanisms and drug discovery of hepatorenal pathologies in RA.

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“…As shown in the review, eight (1.1%) of 727 patients with scleroderma had involvement of the liver [ 9 ]. Primary biliary cirrhosis is the most commonly found hepatic disease in patients with SSc, while autoimmune hepatitis is rare [ 10 , 11 , 12 ].…”

Section: Discussionmentioning

confidence: 99%

Cirrhosis of the Liver: A Case Report and Literature Review of a Rare Case Presentation of Autoimmune Hepatitis With Systemic Sclerosis

Burriwar¹,

Jain²,

Verma³

et al. 2022

Cureus

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Systemic sclerosis (SSc) is a chronic systemic disease that affects the skin, heart, lungs, kidneys, gastrointestinal tract, and musculoskeletal system. Although gastrointestinal involvement has been reported in approximately 90% of scleroderma patients, liver involvement is uncommon. A 51-year-old female was admitted to the hospital due to abdominal distension and pedal edema. She had a history of Raynaud's syndrome and multiple hypopigmented and hyperpigmented patches over her body for the last year. Her ascetic fluid analysis was transudative with a serum ascites albumin gradient >1.1, and the abdomen and pelvis ultrasonography reported liver cirrhosis with splenomegaly with perisplenic varices. Her antinuclear antibody and anti-centromere antibody were positive. Skin thickening was visible. Her alanine aminotransferase (ALT), aspartate aminotransferase (AST), and serum globulin were raised. Viral serology was negative. We managed her with diuretics, beta-blockers, prednisolone (30 mg/day administered orally), angiotensin-converting enzyme inhibitors, and calcium channel blockers. Edema and abdominal distension decreased with this management, and no Raynaud's phenomenon was observed during the hospital stay.

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Autoimmune liver diseases in systemic rheumatic diseases

Cited by 31 publications

References 186 publications

Chronic Nonbacterial Osteomyelitis and Inflammatory Bowel Disease: A Literature Review-Based Cohort

Chronic Nonbacterial Osteomyelitis and Inflammatory Bowel Disease: A Literature Review-Based Cohort

Hepatorenal pathologies in TNF-transgenic mouse model of rheumatoid arthritis are alleviated by anti-TNF treatment

Cirrhosis of the Liver: A Case Report and Literature Review of a Rare Case Presentation of Autoimmune Hepatitis With Systemic Sclerosis

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