Autoimmune lymphocytic thyroiditis in dogs

Gosselin, Sylvie; Capen, C. C.; Martin, S. L.; Krakowka, Steven

doi:10.1016/0165-2427(82)90035-6

Cited by 28 publications

(17 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The combination of clinical and clinicopathological features in this case were consistent with a diagnosis of primary hypothyroidism. Studies report that between 64 and 80 per cent of clinically affected dogs with primary hypothyroidism is a result of autoimmune (lymphocytic and plasmacytic) thyroiditis, a disorder analogous to Hashimoto’s thyroiditis in human beings (Gosselin and others 1982, Dodds 1995). Both cellular and humoral mechanisms of immunity are involved in the pathogenesis of thyroiditis.…”

Section: Discussionmentioning

confidence: 99%

Lymphocytic‐plasmacytic thyroiditis and glomerulonephritis in a boxer

Mansfield¹,

Mooney²

2006

J of Small Animal Practice

View full text Add to dashboard Cite

An 18-month-old boxer was presented for investigation of profound lethargy, and primary hypothyroidism was diagnosed. A strong antithyroglobulin antibody titre was also present, indicating lymphocytic (immune-mediated) thyroiditis as the cause of hypothyroidism. A concurrent protein-losing glomerulonephropathy was also detected, although the aetiology could not be determined at initial presentation. Thyroid replacement and dietary therapy were prescribed. The dog improved clinically for approximately 12 months when it was re-presented with poorly controlled hypothyroidism and renal failure. Postmortem examination confirmed the presence of lymphocytic-plasmacytic thyroiditis, in conjunction with membranoproliferative glomerulonephritis and renal failure.

show abstract

Section: Discussionmentioning

confidence: 99%

Lymphocytic‐plasmacytic thyroiditis and glomerulonephritis in a boxer

Mansfield¹,

Mooney²

2006

J of Small Animal Practice

View full text Add to dashboard Cite

show abstract

“…6,29 Histologic findings for dogs with SEPI showed obvious similarities to lymphocytic thyroiditis, which is reported to be an autoimmune-mediated disease in both dogs and humans. 1,2,7,11,12,21 In both the exocrine pancreas and the thyroid gland, marked infiltration of lymphocytes is associated with gradual destruction of normal follicular parenchyma. 1,7,11,21 Besides lymphocytic thyroiditis, clinical signs of hypothyroidism in dogs have been observed as a result of idiopathic follicular atrophy.…”

Section: Discussionmentioning

confidence: 99%

Exocrine Pancreatic Atrophy in German Shepherd Dogs and Rough-coated Collies: An End Result of Lymphocytic Pancreatitis

Wiberg

Saari

Westermarck³

1999

Vet Pathol

View full text Add to dashboard Cite

Abstract. Previously published studies of the pathology of canine exocrine pancreatic insufficiency (EPI) have been based on morphological findings during the clinical phase of the disease, when atrophy of acinar parenchyma occurs. Recently, low serum trypsinlike immunoreactivity (TLI) concentration has been shown to precede clinical signs, making it possible to diagnose EPI prior to onset of the clinical disease. This study presents histological and ultrastructural findings of pancreatic biopsies from 11 German Shepherd Dogs and 2 Rough-coated Collies with subclinical EPI (SEPI). These findings were compared with those from dogs with clinical EPI (n ϭ 11) and healthy control dogs (n ϭ 5). Biopsied tissue from dogs with SEPI typically contained both normal and atrophied acinar parenchyma. The most significant finding was the marked lymphocytic infiltration, which was most prevalent at the border zone of affected and nonaffected parenchyma but had spread into the normal acinar tissue. Numerous intraacinar lymphocytes were found. Most of the lymphocytes were positive by immunostaining for CD3. In more advanced stages of destruction, the findings were characteristic of pancreatic acinar atrophy. In the atrophied parenchyma, the inflammatory reaction, if present, was less prominent. Ultrastructural changes were in accordance with those of the histological study showing infiltration of lymphocytes both in affected acini and in acini that revealed no obvious ultrastructural changes. Progressive degenerative changes of acinar cells were considered a nonspecific finding. Apoptotic death of acinar cells was occasionally found. The inflammatory reaction was clearly shown to precede the pancreatic acinar atrophy, and the findings suggested that lymphocytic pancreatitis leads to atrophy of the pancreas. The possibility that EPI is an immune-mediated disease in German Shepherd Dogs and Rough-coated Collies is discussed.

show abstract

“…Thyroiditis associated with production of thyroid hormone antibodies has been found in the dog [28][29][30][31] and may be seen in up to one third of dogs with hypothyroidism. 31 Autoimmune thyroiditis, or chronic lymphocytic thyroiditis, is comparable to Hashimoto thyroiditis of humans and is often associated with clinical signs of hypothyroidism.…”

Section: Thyroiditismentioning

confidence: 99%