Autoimmune thyroid diseases and nonorgan‑specific autoimmunity

Lazúrová, Ivica; Benhatchi, Karim

doi:10.20452/pamw.1499

Cited by 30 publications

(25 citation statements)

References 17 publications

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“…AITD is frequently associated with other organ and non-organ-specific autoimmune disorders [8–10]. This association has been also reported in juvenile forms of chronic arthritis and SLE [11, 12].…”

Section: Introductionmentioning

confidence: 90%

High Prevalence of Antinuclear Antibodies in Children with Thyroid Autoimmunity

Segni

Pucarelli

Truglia

et al. 2014

Journal of Immunology Research

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Background. Antinuclear antibodies (ANA) are a hallmark of many autoimmune diseases and can be detected many years before disease onset. Autoimmune thyroid diseases (AITD) are frequently associated with other organ- and non-organ-specific autoimmune disorders. Objectives. To assess the prevalence of ANA in pediatric patients with AITD and their clinical correlations. Methods. Ninety-three consecutive pediatric patients with AITD were enrolled (86 children with chronic lymphocytic thyroiditis and 7 with Graves' disease). ANA, anti-double DNA (anti-dsDNA) antibodies, anti-extractable nuclear antigen (anti-ENA), anti-cyclic citrullinated peptide antibodies (anti-CCP), and rheumatoid factor (RF) was obtained. Signs and symptoms potentially related to rheumatic diseases in children were investigated by a questionnaire. Results. ANA positivity was found in 66/93 children (71%), anti-ENA in 4/93 (4.3%), anti-dsDNA in 1/93 (1.1%), RF in 3/93 (3.2%), and anti-CCP in none. No significant differences were found between the ANA-positive and ANA-negative groups with respect to age, sex, L-thyroxine treatment, or prevalence of other autoimmune diseases. Overall, parental autoimmunity was found in 23%. Conclusions. ANA positivity was demonstrated in 71% of children with AITD. ANA positivity was not related to overt immune-rheumatic diseases. However, because the positivity of ANA can occur even many years before the onset of systemic autoimmune diseases, prospective studies are warranted.

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Section: Introductionmentioning

confidence: 90%

High Prevalence of Antinuclear Antibodies in Children with Thyroid Autoimmunity

Segni

Pucarelli

Truglia

et al. 2014

Journal of Immunology Research

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“…This hypothesis seems to be supported by the fact that there was no statistical significant difference between the subgroups of patients with or without antithyroid antibodies when serological markers of RA such as IgM-RF and ACPA or ANA were concerned. Lazurova et al 16 concluded that there is no evidence for the usefulness of ANA screening in patients with ATD, regarding the coexistence of autoimmune disorders. Although antithyroid antibodies are commonly found in patients with RA and ATD, their relationship with disease activity not only in RA but also in ATD requires more in-depth studies.…”

mentioning

confidence: 99%

Relationship between rheumatoid arthritis activity and antithyroid antibodies

Koszarny¹,

Majdan²,

Suszek³

et al. 2013

Polish Archives of Internal Medicine

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“…[10][11][12][13][14] The objective of this study was to investigate LA mechanical function and its association with LV diastolic function in patients with subclinical hypothyroidism (SHT) and overt hypothyroidism (OHT). To our knowledge, this is the first study to investigate LA mechanical function in hypothyroid patients.…”

mentioning

confidence: 99%

Assessment of left atrial mechanical functions in thyroid dysfunction

Karabağ¹,

Dogan²,

Bayraktaroğlu³

et al. 2013

Polish Archives of Internal Medicine

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IntroductIon Thyroid hormone deficiency can lead to the impairment of cardiac function. objEctIvEs The aim of the study was to determine the left atrial (LA) mechanical function in patients with subclinical hypothyroidism (SHT) and overt hypothyroidism (OHT) and investigate associations of LA mechanical function with diastolic function.PAtIEnts And mEthods Twenty-six patients with newly diagnosed SHT (mean age, 42.2 ±12.5 years), 21 patients with OHT (40.2 ±8.5 years) and 28 healthy volunteers (42.4 ±11.2 years) were enrolled in this study. Patients were evaluated by standard M-mode echocardiographic measurements, mitral Doppler flow analysis, and tissue Doppler parameters at the lateral, septal, and right ventricular annuli. LA volumes were measured using the disc method, and the parameters of LA mechanical function were calculated.rEsuLts The active emptying volume (AEV) and active emptying fraction (AEF) were significantly higher in the OHT and SHT groups compared with controls. The passive emptying volume and passive emptying fraction were lower in the OHT and SHT groups compared with controls, but the differences were not significant. The conduit volume and the E/A ratio were significantly lower in the OHT and SHT groups compared with controls. The lateral and septal E/Em were significantly higher in the OHT and SHT groups than in the control group, but the septal Em/Am was significantly lower. Diastolic function parameters showed significant associations with AEV and AEF.concLusIons LA mechanical function is impaired in patients with thyroid dysfunction. Our findings suggest that this impairment is secondary to that of the left ventricular diastolic function. KEy wordsdiastolic dysfunction, echocardiography, hypothyroidism, left atrial mechanical function orIGInAL ArtIcLE Assessment of left atrial mechanical functions in thyroid dysfunction 597 panels, and fasting glucose levels were measured using venous blood obtained after 8 hours of fasting. An informed consent was obtained from each participant. The study was approved by the local ethics committee.Echocardiographic examination Standard echocardiography was performed using a Vingmed Vivid System 5 device (General Electric, Horten, Norway). A 2.5 MHz probe was used for Doppler measurements and a 2.5-3.5 MHz probe was used for tissue Doppler measurements. All measurements represented an average taken from 3 cardiac cycles. Two-dimensional echocardiographic measurements (LV dimensions, wall thickness, and mitral inflow velocities) were performed were performed according to the standards published by the American Society of Echocardiography. 16 The LV ejection fraction was calculated according to the Simpson method. 17In order to obtain the best signal-to-noise ratio, LV pulsed-tissue Doppler imaging (TDI) was performed in the apical 4-chamber view using a 5-mm pulsed Doppler sample volume with as little optimal gain as possible. Care was taken to align the echo image so that the annular motion was parallel to the TDI cursor. Spectral pulsed-wave D...

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Autoimmune thyroid diseases and nonorgan‑specific autoimmunity

Cited by 30 publications

References 17 publications

High Prevalence of Antinuclear Antibodies in Children with Thyroid Autoimmunity

High Prevalence of Antinuclear Antibodies in Children with Thyroid Autoimmunity

Relationship between rheumatoid arthritis activity and antithyroid antibodies

Assessment of left atrial mechanical functions in thyroid dysfunction

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