Autoimmune Thyroid Disorders in Juvenile Chronic Arthritis and Systemic Lupus Erythematosus

Juvenile Idiopathic Arthritis: Associated and Autoimmune Diseases with the Validity of Das 28

“…The majority (12/14) of children with subclinical hypothyroidism reported in our study did not show findings suggestive of autoimmune thyroiditis, this result is contradictory to Mihailova et al, 1999 andin line with Stagi et al, 2005 and might suggest that thyroid function in JIA could also be impaired in children without an associated autoimmune thyroiditis. Also, it is in conformity with Abd, 2011who found 7 (9.3%) JRA patients showing sub clinical hypothyroidism with one of these presented autoimmune thyroiditis.…”

“…This may reflect how low ATDs diseases among systemic autoimmune diseases In our study 14 cases (14.5%) in JIA group suffered from autoimmune thyroiditis, two (2.1%) of them had subclinical hypothyroidism. Mihailova et al, 1999 previously reported that among 27 JIA children, 44.4% had autoimmune thyroiditis; of these patients 85.2% were euthyroid, and 11.1%had a subclinical hypothyroidism. In line with our study, Alpigiani et al, 2002, examining 66 JIA patients, showed just nine (14%) patients with antithyroid antibodies and all children showed a normal thyroid function.…”

Anemia in thyroid diseases

“…81 The prevalence of elevated antithyroglobulin antibody levels was found to be very high also in children population with juvenile chronic arthritis or SLE, and reached 63% and 58%, respectively. 82 This highlights the importance of screening for other autoimmune diseases if patients with AITD present with new or nonspecific symptoms such as anemia, increased body temperature, and small joint pain, which cannot be entirely attributed to the thyroid disease but may suggest a concomitant rheumatoid disorder. 83…”

Juvenile onset systemic lupus erythematosus thyroid dysfunction: A subgroup with mild disease?

“…Few studies have focused in thyroid involvement in juvenile onset systemic lupus erythematosus and results are still controversial [14][15][16]. We therefore have evaluated the frequency of thyroid dysfunction and the presence of thyroid antibodies in patients with juvenile onset systemic lupus erythematosus (JOSLE) and its possible association with clinical and immunological features.…”