Autoimmunity in Insulin-Dependent Diabetes Mellitus

Bosi, Emanuele; Bottazzo, Gian Franco

doi:10.1007/bf03259274

Cited by 7 publications

(1 citation statement)

References 131 publications

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“…Indeed, many disease-specific autoantibodies (AAb) are detectable prior to the manifestation of the corresponding autoimmune disease. Early diagnosis or the prediction of a risk of developing a disease is becoming more and more important for the elaboration of new prophylactic and therapeutic strategies as has been shown for type 1 diabetes [1]. The combined analyses of ICA, IAA, GAD and IA-2/IA-2ß antibodies have improved the ability to predict diabetes in risk groups as well as in the general population based on the level and number of AAb markers [2].…”

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confidence: 99%

Diagnostic and Prognostic Relevance of Autoantibodies in Uranium Miners

Conrad¹,

Mehlhorn²

2000

Int Arch Allergy Immunol

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Uranium miners exposed to silica dust have a higher risk of developing systemic sclerosis (SSc) and systemic lupus erythematosus (SLE). Sera of 1976 former uranium miners were analysed for autoantibodies typical of connective tissue disease. The frequency of some of these antibodies (anti-centromere, -topoisomerase I, -nucleolar, -dsDNA, -Ro/SSA, -La-SSB and U1-RNP antibodies) was significantly higher compared to a gender- and age-matched control group and was associated with the intensity of exposure as well as with clinical symptoms of SSc or SLE. It was also shown that SSc-associated autoantibodies may serve as an early indicator of disease development. Some differences in the autoantibody production between silica-dust-associated and idiopathic SLE/SSc were observed that might be caused by environmental factors in the population of uranium miners.

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confidence: 99%