Diagnostic and Prognostic Relevance of Autoantibodies in Uranium Miners

Conrad, Karsten; Mehlhorn, J

doi:10.1159/000024426

Cited by 36 publications

(27 citation statements)

References 30 publications

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“…Four of these cases developed CTD that was specific for the corresponding autoantibody, such as anti-RNP for MCTD or anti-SSA for Sjogren's syndrome, and two patients with positive MPO-ANCA developed vasculitis (microscopic polyangiitis). In contrast to ANA (24)(25)(26), only a few previous studies have reported the prevalence of specific autoantibodies in non-CTD individuals; anti-Ro, 2.7%-10.2% (33,34), anti-La, 0.9% (34), anti-Scl70, 0%-3% (35,36), anti-Sm, 0%-0.5% (34,35), which are similar to our results.…”

Section: Discussionsupporting

confidence: 90%

Clinical Significance Of Serum Autoantibodies In Idiopathic Interstitial Pneumonia

Kang

Park

Roh

et al. 2012

D104. Connective Tissue Disease Related-Interstitial Lung Disease: Clinical Features and Treatment

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Section: Discussionsupporting

confidence: 90%

Clinical Significance Of Serum Autoantibodies In Idiopathic Interstitial Pneumonia

Kang

Park

Roh

et al. 2012

D104. Connective Tissue Disease Related-Interstitial Lung Disease: Clinical Features and Treatment

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“…The type and prevalence of disease-specific ANAs have been investigated among specific cohorts, such as consecutive patients and uranium miners [19,20], but few largescale surveys have been conducted within the general population. In our study, the detection of disease-specific ANAs in serum samples from 2181 individuals yielded an anti-SSA/Ro prevalence of 2.7% (3.5% in females; 1.0% in males).…”

Section: Discussionmentioning

confidence: 99%

Prevalence of disease-specific antinuclear antibodies in general population: estimates from annual physical examinations of residents of a small town over a 5-year period

et al. 2008

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The aim of this study was to investigate the types and prevalence of disease-specific antinuclear antibodies (ANAs) and their relationship to rheumatic diseases in the general Japanese population. An immunofluorescence (IF) method was used for the first screening of ANA levels in serum samples obtained from 2181 residents of a small Japanese town. Individuals positive for IF-ANA were then further tested for disease-specific ANAs using eight enzyme immunoassays. Physical status and the presence of illness were determined by means of questionnaires and medical examinations. Based on the result of the IF-ANA assay, the rates of positive samples at 1:40 and 1:160 dilutions were 26.0 and 9.5%, respectively, with females have significantly higher positivity rates than males (P < 0.0001). Among 566 IF-ANA-positive individuals, 100 individuals were found to have 114 disease-specific ANAs. Anti-SSA/Ro, anti-centromere, and anti-U1RNP antibodies were detected in 58, 30, and 11 individuals, respectively, but anti-Sm, anti-Scl-70, and anti-Jo-1 antibodies were undetectable. Questionnaires and medical examinations revealed that among 60 disease-specific ANA-positive individuals that were available for testing, six had Sjögren's syndrome (SS), five were suspected of having SS, and five had rheumatoid arthritis. Surprisingly, 34 (57%) of the disease-specific ANA-positive individuals were clinically healthy. Anti-SSA/Ro, anti-centromere, and anti-U1RNP antibodies were quite frequent among clinically healthy Japanese subjects, although anti-Sm, anti-Scl-70, and anti-Jo-1 antibodies were not. Of the 60 individuals who tested positive for disease-specific ANAs, 30% (18/60) actually manifested systemic rheumatic diseases, while 50% showed no detectable signs or symptoms of rheumatic diseases.

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“…Patients with silicosis and other individuals highly exposed to silica have been shown to have increased autoantibodies (8,9), immunoglobulins, and immune complexes (10). However, a recent study of lupusprone mice demonstrated a decrease in serum immunoglobulin levels associated with the development of autoimmunity (11), and decreased levels of immunoglobulins were observed in foundry and pottery workers working in their jobs for an average of ϳ15 years (12).…”

Section: Introductionmentioning

confidence: 99%

Cell markers, cytokines, and immune parameters in cement mason apprentices

Carlsten¹,

Roos²,

Kaufman³

et al. 2007

Arthritis & Rheumatism

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Objective. Cement masons are known to have significant silica exposure, and silica exposure and silicosis are thought to increase risk of autoimmune disease. Because the mechanisms remain obscure, with inconclusive reports of systemic immune effects following silica exposure, our goal was to identify potential early markers of silica-related immunologic and respiratory effects. Methods. We conducted a cross-sectional study of cement mason apprentices and electrician (control) apprentices. Demographics, dust exposure history, symptoms, spirometry, exhaled nitric oxide, and blood (for immunoglobulins, cytokines, cell counts, and surface markers) were obtained from 11 cement mason apprentices and a comparison group of 21 electrician apprentices. Results. Masons had significantly higher (P < 0.05) masonry dust exposure (42 versus 9 dust-hour-years), serum interleukin-1␤ (IL-1␤; 12 versus 9 pg/ml), IL-2 (20 versus 8 pg/ml), IL-4 (193 versus 67 pg/ml), IL-10 (44 versus 21 pg/ml), and interferon-␥ (139 versus 65 pg/ml) compared with electricians. In contrast, masons had significantly lower percentages of CD25؉ (12% versus 20%) and CD69؉ (4% versus 9%) lymphocytes. Conclusion. Mason apprentices had higher levels of serum proinflammatory cytokines and lower percentages of CD25؉ and CD69؉ lymphocytes than did electrician apprentices. These preliminary findings suggest that mason apprentices may be at greater risk of a systemic proinflammatory state that is potentially linked to immune dysregulation. Although distinct limitations of this preliminary data are recognized, this is consistent with early biologic effects leading to increased incidence of autoimmune disease among silica-exposed workers. Prospective studies are needed to validate these initial findings and clarify the temporal sequence of observed relationships.

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Diagnostic and Prognostic Relevance of Autoantibodies in Uranium Miners

Cited by 36 publications

References 30 publications

Clinical Significance Of Serum Autoantibodies In Idiopathic Interstitial Pneumonia

Clinical Significance Of Serum Autoantibodies In Idiopathic Interstitial Pneumonia

Prevalence of disease-specific antinuclear antibodies in general population: estimates from annual physical examinations of residents of a small town over a 5-year period

Cell markers, cytokines, and immune parameters in cement mason apprentices

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