Autoimmunity in uveitis

Berge, Josianne C. ten; Schreurs, Marco W. J.; Daele, Paul L A van; Rothová, Aniki

doi:10.1111/aos.13652

Cited by 20 publications

(13 citation statements)

References 22 publications

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Section: Animal Model Human Studiesmentioning

confidence: 82%

“…Studies in glaucoma are similar to those in uveitis where there are several relevant animal models of disease and evidence of immune responses to retinal and uveal antigens in humans, but recent studies indicate that only 5% of patients with uveitis have other autoimmune diseases. 19 It may be that there is a small group of patients with glaucoma who have evidence of autoimmunity. In a recent study of 108 patients with NTG from the University Hospital of LMU Munich, only two had additional autoimmune diseases, one had thyroiditis and the other giant cell arteritis, so there was no (significant) association with autoimmune diseases and NTG (unpublished observation by Gerhild Wildner).…”

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confidence: 99%

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Is glaucoma an autoimmune disease?

Wakefield

Wildner

2020

Clin & Trans Imm

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There is increasing evidence from animal and human studies that glaucoma is an autoimmune disease. Evidence for this hypothesis includes the fact that antibodies as well as T‐cell responses to heat‐shock proteins (HSPs) are detectable in some patients with glaucoma and in an animal model of the disease. As in the human disease, experimental animal models of glaucoma have been found to demonstrate neurodegenerative changes in the optic nerve associated with immunoglobulin and T‐cell infiltration. Although there is still insufficient evidence in humans to classify all cases of glaucoma as autoimmune diseases, the implications of this hypothesis have major impact on the diagnosis and treatment of glaucoma.

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Section: Animal Model Human Studiesmentioning

confidence: 82%

mentioning

confidence: 99%

Is glaucoma an autoimmune disease?

Wakefield

Wildner

2020

Clin & Trans Imm

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“…To the best of our knowledge, the epidemiology of infectious uveitis is a complex relationship between microorganisms and humans. The etiology of infectious uveitis varies greatly ( 39 , 40 ). In addition, this study cannot determine the validity of the diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Association Between Air Pollution and the Risk of Uveitis: A Nationwide, Population-Based Cohort Study

et al. 2021

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Previous studies have revealed an association between ocular surface disorders and air pollution, few studies have focused on the risk of uveitis. We aimed to investigate whether air pollution increases the risk of uveitis. We used the Taiwan Longitudinal Health Insurance Database (LHID) and the Taiwan Air Quality Monitoring Database (TAQMD) to conduct a retrospective cohort study. Air pollutant concentrations, including those of carbon dioxide (CO2), were grouped into four levels according to quartiles. The outcome was the incidence of uveitis, as defined in the International Classification of Diseases, Ninth Revision. We used univariable and multivariable Cox proportional hazard regression models to calculate the adjusted hazard ratios (aHRs) and determine the potential risk factors of uveitis. Overall, 175,489 subjects were linked to their nearby air quality monitoring stations. We found that for carbon monoxide, the aHRs of uveitis risk for the Q3 and Q4 levels were 1.41 (95% confidence interval (CI) = 1.23–1.61) and 2.19 (95% CI = 1.93–2.47), respectively, in comparison with those for the Q1 level. For nitric oxide, the aHRs for the Q3 and Q4 levels were 1.46 (95% CI = 1.27–1.67) and 2.05 (95% CI = 1.81–2.32), respectively. For nitrogen oxide (NOx), the aHRs for the Q2, Q3, and Q4 levels were 1.27 (95% CI = 1.11–1.44), 1.34 (95% CI = 1.16–1.53), and 1.85 (95% CI = 1.63–2.09), respectively. For total hydrocarbon (THC), the aHRs for the Q2, Q3, and Q4 levels were 1.42 (95% CI = 1.15–1.75), 3.80 (95% CI = 3.16–4.57), and 5.02 (95% CI = 4.19–6.02), respectively. For methane (CH4), the aHRs for the Q3 and Q4 levels were 1.94 (95% CI = 1.60–2.34) and 7.14 (95% CI = 6.01–8.48), respectively. In conclusion, air pollution was significantly associated with incidental uveitis, especially at high THC and CH4 levels. Furthermore, the uveitis risk appeared to increase with increasing NOx and THC levels.

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“…Cellular infiltration of the vitreous body develops associated with formation of cyclic membranes, complicated cataract, exudative-hemorrhagic forms of inflammation of the choroid and retina. Animal experiments have also shown the important role of nitric oxide (NO) in the pathogenesis of autoimmune uveoretinitis [99]. Retinochoroidopathy appear to be chronic bilateral form of the posterior autoimmune uveitis.…”

Section: Atypical Optic Neuritismentioning

confidence: 99%

Plasmapheresis in Ophthalmology

Voinov

Karchevscy

2019

CTOY

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Loss of sight is one of the most severe disabling factors in human. The total number of such people is known to account for millions worldwide. In North America alone more than 1 million are completely blind and about 14 million have some degree of sight loss. There are many different diseases that lead to sight loss such as diabetic retinopathy, senile macular degeneration, various types of autoimmune retinopathy, optic nerves damage and many others. As a rule, they cannot be corrected with glasses, and not always amenable to drug therapy. Often the cause of these diseases is accumulation of various autoantibodies and other metabolites, the molecules large size of which does not allow them to be excreted by the kidneys and the fact of their accumulation indicates impossibility of their removal with help of drug therapy. It makes us resort to such method of their direct removal from the body as plasmapheresis and the aim of this study is to justify its use in ophthalmology.

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Autoimmunity in uveitis

Abstract: Uveitis and scleritis of autoimmune origin were observed in 5% of the total series. The term autoimmune uveitis should not be used as a synonym for intraocular inflammation of noninfectious origin.

Cited by 20 publications

References 22 publications

Is glaucoma an autoimmune disease?

Is glaucoma an autoimmune disease?

Association Between Air Pollution and the Risk of Uveitis: A Nationwide, Population-Based Cohort Study

Plasmapheresis in Ophthalmology

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