Autoimmunthyreoiditis

Koehler, Viktoria Florentine; Bojunga, Jörg

doi:10.1055/a-1258-5674

Cited by 5 publications

(2 citation statements)

References 31 publications

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“…Die Wahrscheinlichkeit, dass eine Autoimmunerkrankung entsteht, ist zwischen den verschiedenen endokrinen Organen sehr unterschiedlich: Autoimmunerkrankungen der Schilddrüse sind z. B. häufig, solche der Nebenschilddrüsen sehr selten [1].…”

Section: Introductionunclassified

Begleitende Autoimmunphänomene bei Hashimoto-Thyreoiditis

Schinner

2024

Angewandte Nuklearmedizin

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ZusammenfassungAutoimmune Schilddrüsenerkrankungen sind häufig: Die Hashimoto-Thyreoiditis tritt häufiger als der Morbus Basedow auf und hat eine Prävalenz von ca. 1% in Deutschland (definiert nach Antikörpernachweis und typischem Ultraschallbefund). Die Prävalenz von Positivität für Schilddrüsenantikörper ist mit ca. 7% deutlich höher.Diese Erkrankungen können Teil von Autoimmunsyndromen sein. Dies bedeutet, dass es zu einer Häufung verschiedener Autoimmunerkrankungen in einer Person oder einer Familie kommen kann.Es können endokrine Organe (Schilddrüse, Nebenschilddrüsen, Nebennieren, Pankreas, Ovarien), aber auch nicht endokrine Organe betroffen sein: Hierzu zählen die chronische mukokutane Candidiasis, Typ-A-Gastritis, Alopezie, Vitiligo, Zöliakie und Myasthenia gravis.Nach der Kombination dieser Autoimmunerkrankungen ergeben sich Hinweise auf definierte sogenannte polyglanduläre Autoimmunsyndrome.Man definiert das polyglanduläre Autoimmunsyndrom Typ 1 (APS-1) mit den Leiterkrankungen chronische mukokutane Candidiasis, Hypoparathyreoidismus und Morbus Addison.Weiterhin das polyglanduläre Autoimmunsyndrom Typ 2 (APS-2) mit den Leiterkrankungen Diabetes mellitus Typ 1, autoimmune Schilddrüsenerkrankung (Hashimoto-Thyreoiditis/Morbus Basedow) und Morbus Addison.Im Prinzip können diese Erkrankungen zu jedem Lebenszeitpunkt auftreten, wobei es aber Altersgipfel gibt, wann sich die Erkrankungen und Syndrome typischerweise manifestieren.

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Section: Introductionunclassified

Begleitende Autoimmunphänomene bei Hashimoto-Thyreoiditis

Schinner

2024

Angewandte Nuklearmedizin

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“…The 6-methyl-2-thiouracil (MTU) is one of the most widely used anti-thyroid drugs to treat hyperthyroidism in both humans and animals, as it inhibits the formation of T3 (triiodothyronine) and T4 (thyroxine) hormones in the thyroid [1][2][3][4][5][6]. If this substance is consumed to a healthy person or animal, it causes hypothyroidism and a decrease in basal metabolism of the body [7].…”

Section: Introductionmentioning

confidence: 99%

Electrochemical Sensor for the Determination of Methylthiouracil in Meat Samples

Marco

Canals

Morallón

et al. 2022

Sensors

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Two analytical methods based on miniaturized electrochemical sensors, voltammetric and amperometric sensors, have been developed for the determination of 6-methyl-2-thiouracil (MTU) in meat consumption samples (beef liver and foie). A multivariate approach has been considered to optimize the experimental procedure including extraction and electrochemical detection. Under optimal conditions and at a typical working potential of 1.55 V (vs Ag pseudo-reference electrode), response is linear in the range 0 to 20 µg L−1 MTU concentration range. The empirical limit of detection is 0.13 µg L−1, lower than the maximum concentration established by legislation. The electrochemical methods have been used to analyze MTU-spiked meat samples, and recovery values varying between 85 and 95% with coefficients of variation <30%. The analytical methods developed with the miniaturized electrochemical sensors can successfully determine the concentration of MTU in real meat samples with high accuracy, being the results obtained similar to those provided by other methods such as UV-Vis spectrophotometry. Finally, the degree of sustainability of the electrochemical sensors-based developed method has been quantified by means of the Analytical Eco-Scale.

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Consequences of parental preconceptional irradiation: Endocrine-metabolic pathology in offspring

Sosnina

Okatenko

Sokolnikov

2023

Radiac. gig. (2008)

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Epidemiological studies of late effects of preconceptional (prior to conception) radiation exposure are necessary in order to understand the risks of tumor and non-tumor pathology in next generations. Research of possible relation between parental preconceptional exposure and development of endocrine and metabolic disorders in the offspring is one of the topical issues of radiation hygiene. The objective of the study: comparative analysis of endocrine and metabolic pathology in children of the individuals exposed to long term preconceptional external gamma-radiation at the Mayak Production Association – at the first atomic industry facility on Russia. Materials and methods: A retrospective research was performed based on the Ozyorsk Children’s Health Registry. Ozyorsk – the city where Mayak Production Association is the enterprise forming the city. Analysis of endocrine and metabolic disorders was performed for 13880 children of 1949-1973 years of birth who were born and resided in Ozyorsk; parents of 9321 children of this number had accumulated doses of prolonged external gamma-radiation exposure at the production facility prior to conception. A comparative analysis of the structure and incidence of “Endocrine, nutritional and metabolic diseases” and nosological forms of this class of pathology was performed. Characteristic features of parental preconceptional exposure were analyzed in relation to thyroid pathology in children. Relative risk of endocrine and metabolic disorders among the children of exposed and unexposed parents was calculated for the whole disease class and for certain nosologies. Results: A significant predominance of thyroid diseases, particularly, iodine deficiencies, was detected at an earlier age among the offspring of Mayak Production Association workers compared to the control group; these cases were mostly related to low dose parental preconceptional exposure. Thyroid cancer was further detected in 0.16% (15/9321) of the studied cohort of the offspring of exposed parents with average manifestation age of 42.6. Relative risk of thyroid diseases was significantly higher among the exposed parents’ offspring compared to the controls: 2.0 among boys (95% confidence interval 1.38-2.9), 1.59 among girls (1.25-2.02) and in the group as a whole – 1.64 (1.34- 2.01). Relative risk of thyroid diseases related to iodine deficiency among the offspring of Mayak Production Association personnel was almost twice higher than the in the control group: 1.92 (1.3-2.84) among boys, 1.68 (1.29-2.2) among girls, 1.7 (1.36-2.12) in the whole group. Discussion and conclusion: A statistically significant overweight of non-tumor thyroid pathology in the offspring of Mayak Production Association personnel cannot be explained through external reasons taking into account similar climate and geographic conditions, possible technogenic exposure and the same unified medical survey of the followed children. We cannot exclude increased sensibility if thyroid tissue to iodine deficiency and its predisposition to hypertrophy and hyperplasia among the offspring of individuals exposed to long term occupational contact with ionizing radiation sources; that should be taken into account in the course of medical monitoring of these patients. Further research of transgenerational effects in the offspring of personnel of radiation hazardous production facilities are needed for complete understanding of the role of parental occupational exposure in health risks for further generations.

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Autoimmunthyreoiditis

Cited by 5 publications

References 31 publications

Begleitende Autoimmunphänomene bei Hashimoto-Thyreoiditis

Begleitende Autoimmunphänomene bei Hashimoto-Thyreoiditis

Electrochemical Sensor for the Determination of Methylthiouracil in Meat Samples

Consequences of parental preconceptional irradiation: Endocrine-metabolic pathology in offspring

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