Autoinducer-2 of gut microbiota, a potential novel marker for human colorectal cancer, is associated with the activation of TNFSF9 signaling in macrophages

Li, Qing; Peng, Wei; Wu, Jiao; Wang, Xianfei; Ren, Yixing; Li, Huan; Yan, Peng; Tang, Xiaowei; Fu, Xiangsheng

doi:10.1080/2162402x.2019.1626192

Cited by 23 publications

(25 citation statements)

References 48 publications

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“…AI-2, continuously secreted by different intestinal bacteria, especially those near the epithelia, can regulate negative-feedback of inflammatory response for immune tolerance. For example, TNFSF9 gene expression was significantly upregulated in AI-2 stimulated macrophages ( Li et al, 2019 ). Indole can be recognized by aryl hydrocarbon receptor (AHR) and bind the pregnane X receptor (PXR) in IECs ( Hubbard et al, 2015 ).…”

Section: Qs In the Gastrointestinal Tractmentioning

confidence: 99%

Bacterial Quorum-Sensing Systems and Their Role in Intestinal Bacteria-Host Crosstalk

Luo

2021

Front. Microbiol.

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Quorum-sensing (QS) system is a rapidly developing field in which we are gradually expanding our understanding about how bacteria communicate with each other and regulate their activities in bacterial sociality. In addition to collectively modifying bacterial behavior, QS-related autoinducers may also be embedded in the crosstalk between host and parasitic microbes. In this review, we summarize current studies on QS in the intestinal microbiome field and its potential role in maintaining homeostasis under physiological conditions. Additionally, we outline the canonical autoinducers and their related QS signal-response systems by which several pathogens interact with the host under pathological conditions, with the goal of better understanding intestinal bacterial sociality and facilitating novel antimicrobial therapeutic strategies.

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Section: Qs In the Gastrointestinal Tractmentioning

confidence: 99%

Bacterial Quorum-Sensing Systems and Their Role in Intestinal Bacteria-Host Crosstalk

Luo

2021

Front. Microbiol.

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“…AI-2 in the gut: AI-2 presence in the gut has been reported by several articles[ 19 , 40 , 41 ] but is mainly linked to pathogenic bacteria such as enterohemorrhagic E. coli [ 19 ]. As AI-2 is considered a “universal language”, it is not surprising to find this AI in an ecosystem as diverse as the gut microbiota.…”

Section: Qs: Gossip In a Bacterial Worldmentioning

confidence: 99%

“…In mice, AI-2 administration has no effect by itself on cytokine expression but aggravates lung inflammation during P. aeruginosa infection by interfering with QS molecules produced by this pathogen[ 119 ]. In cultured macrophages, AI-2 induces the expression of several cytokines and chemokines as well as the expression of TNF superfamily member 9 (TNFSF9), a protein involved in the immune response[ 41 ] (Figure 3 ).…”

Section: Host: “You’ve Got Mail”mentioning

confidence: 99%

“…Recent findings provide new insights into the role of the QS molecule AI-2 in intercellular communication during CRC. First, the AI-2 concentration is increased in tumors compared to the surrounding normal tissue in human CRC[ 41 ]. These levels also correlate with the progression of the disease according to the CRC TNM (tumor node and metastasis) score[ 41 ].…”

Section: Host: “You’ve Got Mail”mentioning

confidence: 99%

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Gossip in the gut: Quorum sensing, a new player in the host-microbiota interactions

Coquant¹,

Aguanno²,

Pham³

et al. 2021

WJG

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Bacteria are known to communicate with each other and regulate their activities in social networks by secreting and sensing signaling molecules called autoinducers, a process known as quorum sensing (QS). This is a growing area of research in which we are expanding our understanding of how bacteria collectively modify their behavior but are also involved in the crosstalk between the host and gut microbiome. This is particularly relevant in the case of pathologies associated with dysbiosis or disorders of the intestinal ecosystem. This review will examine the different QS systems and the evidence for their presence in the intestinal ecosystem. We will also provide clues on the role of QS molecules that may exert, directly or indirectly through their bacterial gossip, an influence on intestinal epithelial barrier function, intestinal inflammation, and intestinal carcinogenesis. This review aims to provide evidence on the role of QS molecules in gut physiology and the potential shared by this new player. Better understanding the impact of intestinal bacterial social networks and ultimately developing new therapeutic strategies to control intestinal disorders remains a challenge that needs to be addressed in the future.

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“…Moreover, Mast Cell activation through the mast-cell-specific GPCR, MRGPRX2, which are Gram-positive QSMs receptors [ 221 ] leads to degranulation and release of ROS, TNF-α, and Prostaglandin D2, thereby triggering a local inflammatory response. In 2019, the association between gut microbiota-derived AI-2 and the progression of colorectal cancer (CRC) has been highlighted [ 222 ]. This association was mediated by tumor-associated immune cells, such as macrophages.…”

Section: Microbiota-derived Metabolites That Modulate Host Immunity In the Gutmentioning

confidence: 99%

What We Know So Far about the Metabolite-Mediated Microbiota-Intestinal Immunity Dialogue and How to Hear the Sound of This Crosstalk

et al. 2021

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Trillions of microorganisms, termed the “microbiota”, reside in the mammalian gastrointestinal tract, and collectively participate in regulating the host phenotype. It is now clear that the gut microbiota, metabolites, and intestinal immune function are correlated, and that alterations of the complex and dynamic host-microbiota interactions can have deep consequences for host health. However, the mechanisms by which the immune system regulates the microbiota and by which the microbiota shapes host immunity are still not fully understood. This article discusses the contribution of metabolites in the crosstalk between gut microbiota and immune cells. The identification of key metabolites having a causal effect on immune responses and of the mechanisms involved can contribute to a deeper insight into host-microorganism relationships. This will allow a better understanding of the correlation between dysbiosis, microbial-based dysmetabolism, and pathogenesis, thus creating opportunities to develop microbiota-based therapeutics to improve human health. In particular, we systematically review the role of soluble and membrane-bound microbial metabolites in modulating host immunity in the gut, and of immune cells-derived metabolites affecting the microbiota, while discussing evidence of the bidirectional impact of this crosstalk. Furthermore, we discuss the potential strategies to hear the sound of such metabolite-mediated crosstalk.

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Autoinducer-2 of gut microbiota, a potential novel marker for human colorectal cancer, is associated with the activation of TNFSF9 signaling in macrophages

Cited by 23 publications

References 48 publications

Bacterial Quorum-Sensing Systems and Their Role in Intestinal Bacteria-Host Crosstalk

Bacterial Quorum-Sensing Systems and Their Role in Intestinal Bacteria-Host Crosstalk

Gossip in the gut: Quorum sensing, a new player in the host-microbiota interactions

What We Know So Far about the Metabolite-Mediated Microbiota-Intestinal Immunity Dialogue and How to Hear the Sound of This Crosstalk

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