Autologous chondrocyte implantation for focal cartilage defects in athletes: histology and second-look arthroscopy

Santori, N.; Massaro, Gianluca; Santori, F. S.

doi:10.1007/s10195-004-0051-8

Cited by 6 publications

(4 citation statements)

References 17 publications

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“…18 However, it should be noted that several studies have shown that improvements in pain and functional scores after ACI have better longevity than other techniques, especially in athlete populations, which are likely to constitute the best representation of adolescent populations with respect to relative activity levels. 8,12,27,58 Moreover, it has been noted that ACI is a more expensive procedure than other cartilage repair procedures. However, the long-term cost-effectiveness of ACI has been described in several studies.…”

Section: Discussionmentioning

confidence: 99%

Long-term Outcomes of Autologous Chondrocyte Implantation in Adolescent Patients

2017

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ACI resulted in satisfactory survival rates and significant improvements in function, pain, and mental health for adolescent patients over a long-term follow-up. ACI was associated with very high satisfaction postoperatively, despite the subsequent procedure rate being relatively high primarily because of the use of periosteum. If periosteum is used, this rate should be a consideration when discussing ACI with patients and their parents.

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Section: Discussionmentioning

confidence: 99%

Long-term Outcomes of Autologous Chondrocyte Implantation in Adolescent Patients

2017

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“…Thirteen studies were identified that reported data on histological outcomes of ACI-P knee cartilage repair (Table 3, Appendix). [6,8,20,25,26,27,30,31,34,38,42,45,51] The 13 studies included data from 489 patients and reported data on 272 biopsy samples. Of the 272 biopsy specimens, 84 (30.9%) showed hyaline cartilage only.…”

Section: Autologous Chondrocyte Implantation With Periosteum Cover (Amentioning

confidence: 99%

Correlation between histological outcome and surgical cartilage repair technique in the knee: A meta-analysis

et al. 2016

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“…[18][19][20][21] ACI has demonstrated successful graft incorporation with histology closely matching native hyaline cartilage. 22,23 Young patients have comparable, if not improved, knee functional outcome scores and 10-year survivorship approaching 90% when comparing ACI to other surgical techniques. 20,[24][25][26][27][28] Although studies corroborate the success of ACI, donor site morbidity remains a concern.…”

Section: Discussionmentioning

confidence: 94%

“…In 1743, William Hunter highlighted that “ulcerated cartilage is a troublesome thing, once destroyed it is not repaired.”17 Although many years later it remains true that there is limited biological regenerative capacity to restore articular cartilage, ACI has shown promise in the treatment of full-thickness cartilage defects larger than 2 cm² in younger patients 18–21. ACI has demonstrated successful graft incorporation with histology closely matching native hyaline cartilage 22,23. Young patients have comparable, if not improved, knee functional outcome scores and 10-year survivorship approaching 90% when comparing ACI to other surgical techniques 20,24–28.…”

Section: Discussionmentioning

confidence: 99%

Loose Body Versus Trochlear Biopsy Matrix-Induced Autologous Chondrocyte Implantation (MACI) MOCART Scores and IKDC Reported Outcomes in Pediatric Patients

Hill

Delman

Shelton

et al. 2022

Journal of Pediatric Orthopaedics

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Background: Matrix-induced autologous chondrocyte implantation (MACI) has shown promising results in the treatment of osteochondral lesions of the knee. A recent study showed similar viability comparing chondrocytes harvested from the intercondylar notch compared to those harvested from osteochondral loose bodies. However, there is limited evidence assessing how these different biopsies perform clinically. The goal of this study was to compare both radiographic and patient-reported outcomes in patients with patellar and femoral osteochondral lesions treated with MACI using either a standard intercondylar notch biopsy or an osteochondral loose body biopsy. Methods: A retrospective study was performed on all pediatric autologous chondrocyte implantation procedures performed from 2014 to 2017 at a single institution. Patients were divided into 2 groups: one group had cartilage derived from a standard intercondylar notch biopsy (n = 9) and the other group had cartilage derived from an osteochondral loose body found within the ipsilateral knee (n = 10). At a minimum of 1-year postimplantation, magnetic resonance imagings of the operative knee were performed and the Magnetic Resonance Observation of Cartilage Repair Tissue Knee Score (MOCART 2.0) knee score was used to assess the integrity and quality of the cartilage repair tissue. Interclass correlation coefficients were calculated between the 2 groups. International Knee Documentation Committee (IKDC) outcome scores were determined at a minimum 2 years post-implantation. Results: The interclass correlation coefficient between three independent examiners for the MOCART scoring was excellent at 0.94. With regards to the MOCART score, the loose body group had an insignificant 17-point lower median score at 63 [interquartile range (IQR): 58 to 89] compared to the intercondylar group at 80 (IQR: 65 to 90) (P = 0.15). There was no difference in IKDC scores with the loose body group having a median score of 82 (IQR: 65 to 95) and the intercondylar group having a median score of 84 (IQR: 53 to 99) (P = 0.90). Conclusion: These results demonstrate that osteochondral loose bodies can be used as viable harvest site in MACI procedures with no difference in functional and radiographic outcomes at 2 years postimplantation. This may limit both short and longterm donor site morbidity.

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Autologous chondrocyte implantation for focal cartilage defects in athletes: histology and second-look arthroscopy

Cited by 6 publications

References 17 publications

Long-term Outcomes of Autologous Chondrocyte Implantation in Adolescent Patients

Long-term Outcomes of Autologous Chondrocyte Implantation in Adolescent Patients

Correlation between histological outcome and surgical cartilage repair technique in the knee: A meta-analysis

Loose Body Versus Trochlear Biopsy Matrix-Induced Autologous Chondrocyte Implantation (MACI) MOCART Scores and IKDC Reported Outcomes in Pediatric Patients

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