Autologous chondrocyte implantation for full thickness articular cartilage defects of the knee

Vasiliadis, Haris S.; Wasiak, Jason

doi:10.1002/14651858.cd003323.pub3

Cited by 136 publications

(103 citation statements)

References 65 publications

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“…Previous studies have investigated tissue engineering and cellular therapies for treating early stage OA, and autologous chondrocyte implantation has demonstrated positive clinical outcomes (9,10). Nevertheless, due to the poor self-renewal and regeneration potential of chondrocytes, it is a slow process that may lead to fibrocartilage rather than hyaline cartilage (11,12). Furthermore, this two-stage surgical procedure and is predominantly used to treat cartilage defects caused by injury rather than OA.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of mesenchymal stem cells in treating patients with osteoarthritis of the knee: A meta-analysis

Cui

Wang

et al. 2016

Experimental and Therapeutic Medicine

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Abstract. To assess the clinical efficacy and safety of mesenchymal stem cell (MSC) treatment for osteoarthritis of the knee (KOA), a systematic electronic literature search was performed on PubMed, EMBASE and Web of Science. Studies published in English from the earliest record to December 2014 were searched using the following keywords: Cartilage defect, cartilage repair, osteoarthritis, KOA, stem cells, MSCs, bone marrow concentrate (BMC), adipose-derived mesenchymal stem cells, synovial-derived mesenchymal stem cells and peripheral blood-derived mesenchymal stem cells. The effect sizes of selected studies were determined by extracting pain scores from the visual analog scale and functional changes from International Knee Documentation Committee and Lysholm and Western Ontario and McMaster Universities Osteoarthritis Index before and after MSCs or reference treatments at 3, 6, 12, and 24 months. The factors were analyzed and the outcomes were modified after comparing the MSC group pooled values with the pretreatment baseline or between different treatment arms. A systematic search identified 18 clinical trials on this topic, including 10 single-arm prospective studies, four quasi-experimental studies and four randomized controlled trials that used BMCs to treat 565 patients with KOA in total. MSC treatment in patients with KOA showed continual efficacy for 24 months compared with their pretreatment condition. Effectiveness of MSCs was improved at 12 and 24 months post-treatment, compared with at 3 and 6 months. No dose-responsive association in the MSCs numbers was demonstrated. However, patients with arthroscopic debridement, activation agent or lower degrees of Kellgren-Lawrence grade achieved improved outcomes. MSC application ameliorated the overall outcomes of patients with KOA, including pain relief and functional improvement from basal evaluations, particularly at 12 and 24 months after follow-up.

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Section: Introductionmentioning

confidence: 99%

Efficacy of mesenchymal stem cells in treating patients with osteoarthritis of the knee: A meta-analysis

Cui

Wang

et al. 2016

Experimental and Therapeutic Medicine

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“…Не было зафиксировано статистически значимой разницы в функциональных результатах в двух исследованиях, сравнивающих АТХ с МФ. Оценка результатов шестого исследования, в котором сравнивались АТХ и МФ, была ограничена из-за большого числа выпадений из-под на-блюдения [82].…”

Section: ау тологичная трансплантация хондроцитовunclassified

Osteoarthritis: Current Clinical Concept and Some Promising Therapeutic Approaches

Каратеев¹,

Лила²

2018

rsp

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“…A recent systematic review [Harris 2010] comparing these two techniques, looked at two other studies [Horas 2003 Despite the increasingly widespread use of autologous chondrocyte implantation, it remains unclear as to whether there is a significant difference between this and other cartilage repair techniques. A Cochrane Database Systematic Review [Vasiliadis 2010] concluded that there was insufficient evidence to draw conclusions on the use of autologous chondrocyte implantation in the knee.…”

Section: Autologous Chondrocyte Implantationmentioning

confidence: 99%

Surgery for Osteoarthritis of the Knee

Lewis¹,

Smith²

2012

Osteoarthritis - Diagnosis, Treatment and Surgery

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Autologous chondrocyte implantation for full thickness articular cartilage defects of the knee

Abstract: Autologous chondrocyte implantation for full thickness articular cartilage defects of the knee.

Cited by 136 publications

References 65 publications

Efficacy of mesenchymal stem cells in treating patients with osteoarthritis of the knee: A meta-analysis

Efficacy of mesenchymal stem cells in treating patients with osteoarthritis of the knee: A meta-analysis

Osteoarthritis: Current Clinical Concept and Some Promising Therapeutic Approaches

Surgery for Osteoarthritis of the Knee

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