Autologous Chondrocyte Implantation

Abstract

Cartilage repair or restoration in the knee provides short-term success with microfracture, autologous chondrocyte implantation, or osteochondral autograft. There are patient-specific and defect-specific factors that influence clinical outcomes.

The Role of Environmental Factors in Regulating the Development of Cartilaginous Grafts Engineered Using Osteoarthritic Human Infrapatellar Fat Pad–Derived Stem Cells

“…Autologous chondrocyte implantation (ACI) has been used with reasonable success to treat focal lesions in the knee joint 2,3 ; however, it is still unclear whether ACI is superior to other treatment strategies. [4][5][6] Further, the ACI technique suffers from a number of technical disadvantages, including the need to biopsy regions of the undamaged joint surface to isolate chondrocytes and the dedifferentiation of these chondrocytes during monolayer expansion. [7][8][9] This has led to increased interest in the use of mesenchymal stem cells (MSCs) for the treatment of damaged and diseased articular cartilage.…”

Komplexe Gelenkrekonstruktion und Gelenktransplantation mit dem FLOCSAT-Konzept – Planung und chirurgische Umsetzung

“…Mikrofrakturierung (MF), autologe Chondrozytentransplantation (ACT), autologe matrixinduzierte Chondrogenese (AMIC) und andere Therapien sind wichtige Optionen zur Behandlung chondraler Läsionen. Bei großen subchondralen Läsionen, fehlendem intakten Knorpelrand [2,4,7,11,14], gegenüberliegenden ("kissing") Läsio- nen oder großen Knorpel-KnochenDefekten (> 10 cm 2 ) sind sie jedoch weniger geeignet. Die Heilung erfolgt hier über die Bildung eines Faserknorpels, dieser entspricht jedoch histologisch und somit auch biomechanisch nicht dem eines vollwertigen hyalinen Knorpels.…”

Strategies for Improving the Repair of Focal Cartilage Defects

“…Lately, several systematic reviews have been published on the comparison of ACI with the two other surgical techniques [26][27][28][29][30]. These reviews could not conclude on the superiority of ACI over MF and osteochondral autograft transfer.…”