Autologous Collagen-Induced Chondrogenesis Using Fibrin and Atelocollagen Mixture

Abstract

For articular cartilage defect treatment, many treatment modalities have been developed. We evaluate the cartilage repair potential of an atelocollagen and fibrin mixture transplanted to cartilage defects. A circular, articular cartilage defect 4 mm in diameter was made in the trochlear region in each of 20 New Zealand white rabbits. The 10 rabbits in the control group were kept without treatment and the 10 rabbits in the experimental group underwent injection of atelocollagen mixed with fibrin. At week 12 following surgery the cartilage was observed and histologically compared in both groups. The surface of the newly generated cartilage was very smooth and even, and we also noted that the entire area was completely regenerated in the experimental group. The control group showed incomplete and irregular cartilage formation in the defect. Regarding the histological scoring, comparison of the two groups differed significantly (p < 0.001). Injection of a mixture of atelocollagen and fibrin used to treat articular cartilage defects of the knee appears to be an effective method for cartilage regeneration.

Fabrication and characterization of three-dimensional poly(lactic acid-co-glycolic acid), atelocollagen, and fibrin bioscaffold composite for intervertebral disk tissue engineering application

“…Few reports suggested the combination of atelocollagen and fibrin in articular cartilage defect and osteochondral lesion. [22][23][24] Hence, it would be of interest to study the combination of atelocollagen and fibrin incorporated onto PLGA scaffold for IVD regeneration.…”

Enhancement of Healing of Long Tubular Bone Defects in Rabbits Using a Mixture of Atelocollagen Gel and Bone Marrow Aspirate Concentrate

“…Therefore, it has been used to treat fractures, articular defects, and soft tissue damage, and positive clinical results have been reported [Kagawa et al, 2012;Volpi et al, 2014;Kim et al, 2015]. As it is a gel, it can be applied to small defects or to fracture lines that cannot be filled by bone grafts or solid scaffolds, and it remains in the injected area because of its viscosity [Chaipinyo et al, 2004;Mimura et al, 2008;Jeong et al, 2013]. Although some spreading does occur, it is safe, as the main material that constitutes the human body is collagen; hence, atelocollagen does not cause an immune response and it is biodegradable [Yamaoka et al, 2010;Ye et al, 2016].…”

Improved Healing of Rabbit Patellar Tendon Defects After an Atelocollagen Injection

“…Atelocollagen has been considered to have good potential for clinical application, as it has been reported to maintain collagen characteristics. 7,8…”

“…Atelocollagen has been considered to have good potential for clinical application, as it has been reported to maintain collagen characteristics. 7,8 Given that atelocollagen enhances tissue-specific regeneration, 9 the treatment effect of atelocollagen gel in the patellar tendon defect was evaluated using histologic staining and biomechanical test. To the best of our knowledge, this is the first study to evaluate the regeneration of an injured patellar tendon using an atelocollagen gel injection.…”