Autologous Flap Transfer for Esophageal Stricture Prevention After Endoscopic Submucosal Dissection in a Porcine Model

Tang, Airong; Pingping, Deng; Zhang, Hanqing; Xu, Yang; Min, Min; Liu, Yan

doi:10.1007/s10620-018-5094-4

Dig Dis Sci

2018

DOI: 10.1007/s10620-018-5094-4

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Autologous Flap Transfer for Esophageal Stricture Prevention After Endoscopic Submucosal Dissection in a Porcine Model

Airong Tang

Deng Pingping

Hanqing Zhang

et al.

Abstract: Autologous flap transfer after circumferential esophageal endoscopic submucosal dissection is a novel approach that remarkably decreases the degree of esophageal stricture that arises.

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Esophageal regenerative therapy using cell sheet technology

Ohki

Yamamoto

2020

Regenerative Therapy

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We have been conducting research on esophageal regenerative therapy using cell sheet technology. In particular, in the endoscopic field, we have pushed forward clinical research on endoscopic transplantation of cultured autologous oral mucosal epithelial cell sheets to esophageal ulcer after endoscopic submucosal dissection (ESD). We started research in this direction using animal models in 2004 and performed clinical research in 2012 in collaboration with Nagasaki University and Karolinska Institute. Although in full-circumferential cases it was difficult to prevent esophageal stricture after ESD, there were no complications and stricture could be suppressed. The cell sheet technology is still in its infancy. However, we are convinced that it has a high potential for application in various areas of gastrointestinal science. In this review, we focus on the pre-clinical and clinical trial results obtained and on the theoretical aspects of (1) stricture prevention, (2) esophageal tissue engineering research, and (3) endoscopic transplantation, and review the esophageal regenerative therapy by cell sheet technology.

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Esophageal regenerative therapy using cell sheet technology

Ohki

Yamamoto

2020

Regenerative Therapy

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show abstract

Progress of esophageal stricture prevention after endoscopic submucosal dissection by regenerative medicine and tissue engineering

Zhou

et al. 2021

Regenerative Therapy

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Autologous Flap Transfer for Esophageal Stricture Prevention After Endoscopic Submucosal Dissection in a Porcine Model

Abstract: Autologous flap transfer after circumferential esophageal endoscopic submucosal dissection is a novel approach that remarkably decreases the degree of esophageal stricture that arises.

Cited by 2 publications

References 26 publications

Esophageal regenerative therapy using cell sheet technology

Esophageal regenerative therapy using cell sheet technology

Progress of esophageal stricture prevention after endoscopic submucosal dissection by regenerative medicine and tissue engineering

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