Autologous hematopoietic stem cell transplantation for intravascular large B-cell lymphoma: the European Society for Blood and Marrow Transplantation experience

Meißner, Julia; Finel, Hervé; Dietrich, Sascha; Boumendil, Ariane; Kanfer, Edward; Labouré, Gaëlle; Abecasis, Manuel; Cornelissen, Jan J.; Delage, Jérémy; Finke, Jürgen; Hess, U.; Ludwig, Heinz; Mohty, Mohamad; Pabst, Thomas; Pioltelli, Pietro; Robinson, Stephen; Samaras, Panagiotis; Montoto, Silvia; Dreger, Peter

doi:10.1038/bmt.2016.339

Cited by 27 publications

(16 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Overall survival of patients with CNS involvement of IVLBCL, treated (with classical treatment) or not, is very poor (<1 year), but complete remission has been reported in some cases [14, 18, 19]. Autologous hematopoietic stem cell transplantation is reported to be successful in almost all cases [24].…”

Section: Discussionmentioning

confidence: 99%

Pituitary Gland and Neurological Involvement in a Case of Hemophagocytic Syndrome Revealing an Intravascular Large B-Cell Lymphoma

Njonnou

Couturier

Gombeir

et al. 2019

Case Reports in Hematology

View full text Add to dashboard Cite

Intravascular large B-cell lymphoma is a rare entity characterized by the proliferation of neoplastic lymphocytes in the lumen of small blood vessels and high mortality. Diagnosis of intravascular lymphoma is often delayed or established postmortem. Here, we report the case of a 48-year-old woman presenting hemophagocytic syndrome, with pituitary gland and neurological involvement. Diagnosis of intravascular large B-cell lymphoma was made on perisplenic vessels, while liver and bone marrow biopsy was noncontributive. This case demonstrates the importance of thorough histopathologic investigations in the setting of high suspicion.

show abstract

Section: Discussionmentioning

confidence: 99%

Pituitary Gland and Neurological Involvement in a Case of Hemophagocytic Syndrome Revealing an Intravascular Large B-Cell Lymphoma

Njonnou

Couturier

Gombeir

et al. 2019

Case Reports in Hematology

View full text Add to dashboard Cite

show abstract

“…In a retrospective study, autologous stem cell transplantation showed a clinical improvement in comparison with R-CHOP treatment. However, it appears feasible only in a small proportion of patients with IVLBCL considering a median age of 70 years and generally poor PS 61 in which this option cannot be applied. Experience with new drugs is limited and cases with poor success have been reported.…”

Section: Therapymentioning

confidence: 99%

Intravascular large B-cell lymphoma: a chameleon with multiple faces and many masks

Ponzoni

Campo

Nakamura

2018

Blood

197

259

View full text Add to dashboard Cite

Intravascular large B-cell lymphoma (IVLBCL) is a rare, clinically aggressive lymphoma entity characterized by an almost exclusive growth of large cells within the lumen of all sized blood vessels. The reasons for this peculiar localization of neoplastic cells are only partially understood. Clinically, in its classical variant, IVLBCL presents with many nonspecific signs and symptoms such as fever of unknown origin and involvement of the central nervous system and skin. Cases, which show disease limited to the skin, following extensive staging workup, are called cutaneous variants and show a better prognosis. In addition, a hemophagocytic variant associated with hemophagocytic syndrome and often with hepatosplenic involvement and cytopenia has been described. The classical and hemophagocytic variants are present mainly in western or Asian countries, respectively, although exceptions have been increasingly reported in both geographical areas. The cutaneous variant is mostly observed in western countries. Staging of IVLBCL is difficult and still not satisfactory. The often poor prognosis of this type of lymphoma has been substantially improved by immunochemotherapy, in particular with rituximab. Despite improved outcome, a significant proportion of patients relapse, in particular those with central nervous system manifestations. This review focuses on histopathological features, pathogenetic elements, presenting symptoms, clinical variants, disease progression, prognostic factors, therapeutic management, and the outcome of IVLBCL.

show abstract

“…A registry-based study from the European Society for Blood and Marrow Transplantation (EBMT) suggested the favorable outcome of upfront ASCT in 11 patients with IVLBCL [ 21 ]. Our study also showed better outcomes for upfront ASCT than for salvage ASCT because two patients receiving upfront ASCT including one patient with CNS involvement were still alive without relapse at the end of the study period ( Fig.…”

Section: Discussionmentioning

confidence: 99%

Asian variant of intravascular large B-cell lymphoma: a comparison of clinical features based on involvement of the central nervous system

Yoon

Kim

2020

Korean J Intern Med

View full text Add to dashboard Cite

Background/Aims: There are limited data about the influence of the central nervous system (CNS) involvement on the prognosis for patients with the Asian variant of intravascular large B-cell lymphoma (IVLBCL). Methods: We analyzed 46 patients who were diagnosed with IVLBCL between 2001 and 2018. All patients were treated with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP). Results: CNS involvement was diagnosed by cerebrospinal fluid analysis (n = 6) and brain imaging (n = 5) in 11 patients at diagnosis, and four cases with CNS relapse were found. Thus, 15 patients had CNS involvement (15/46, 33%). The clinical characteristics were not different between patients with and without CNS involvement, but all patients with CNS involvement belonged to the high-risk group of CNS-International Prognostic Index (IPI). Thirty-one patients achieved a complete response (67%, 31/46) whereas eight patients showed disease progression and six patients died after the first or second cycle of R-CHOP. CNS-directed therapy such as high-dose methotrexate was combined with R-CHOP for patients with CNS involvement, and five patients were alive without relapse. The median overall survival of all patients was 45.0 months, and overall survival was not different according to the involvement of CNS. Conclusions: The treatment outcome of patients with the Asian variant of IVLB-CL is still not satisfactory. The prediction of CNS involvement based on the clinical features including CNS-IPI score might not serve to identify patients at high risk of CNS involvement, either. Thus, more effective strategies for diagnosis and treatment should be developed.

show abstract

Autologous hematopoietic stem cell transplantation for intravascular large B-cell lymphoma: the European Society for Blood and Marrow Transplantation experience

Cited by 27 publications

References 13 publications

Pituitary Gland and Neurological Involvement in a Case of Hemophagocytic Syndrome Revealing an Intravascular Large B-Cell Lymphoma

Pituitary Gland and Neurological Involvement in a Case of Hemophagocytic Syndrome Revealing an Intravascular Large B-Cell Lymphoma

Intravascular large B-cell lymphoma: a chameleon with multiple faces and many masks

Asian variant of intravascular large B-cell lymphoma: a comparison of clinical features based on involvement of the central nervous system

Contact Info

Product

Resources

About