Autologous Platelet Concentrates as a Treatment of Horses with Osteoarthritis: A Preliminary Pilot Clinical Study

Carmona, JU; Argüelles, D.; Climent, F.; Prades, Marta

doi:10.1016/j.jevs.2007.02.007

Cited by 85 publications

(130 citation statements)

References 7 publications

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“…It is important to bear in mind that, during the six-month period, the positively responded horses returned to their regular athletic activities with the majority of them maintaining high performance levels. As aforementioned, in a similar study in equine patients, the lameness improvement was most significant two months post-therapy and persisted for eight months (Carmona et al 2007). In most human studies, especially in young patients and in low-severity osteoarthritis, function improvement and control of pain were also stable for a shortterm period (usually six months) (Kon et al 2010;Patel et al 2013;Monteiro et al 2015).…”

Section: Discussionmentioning

confidence: 53%

“…Similarly, in four horses with osteoarthritis of different joints including the distal interphalangeal joint, intra-articular injections of autologous platelet concentrate induced a significant improvement in lameness that persisted for 2À8 months over a one-year follow-up period (Carmona et al 2007). Furthermore, the use of an autologous platelet concentrate in 20 athletic horses with refractory fetlock osteoarthritis gave better results; one year post-treatment the 80% of treated horses returned to work (Pichereau et al 2014).…”

Section: Discussionmentioning

confidence: 91%

“…Although the existence of growth factors has been well known since many years, the application of platelet-derived therapies in musculoskeletal injuries and especially osteoarthritis, in both human and veterinary medicine, has been popularized the last decades (Carmona et al 2007;S anchez et al 2008;Kon et al 2010;Nguyen et al 2011;Textor 2011). Growth factors released mainly from platelet a-granules are a group of biologically active polypeptides with anabolic and anticatabolic effects that may regulate neo-chondrogenesis, as well as chondrocyte metabolism and differentiation, potentially improving cartilage repair (Van Den Berg et al 2001;Sun et al 2010;Fortier et al 2011;Xie et al 2014).…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of intra-articular injection of autologous platelet lysate (PL) in horses with osteoarthritis of the distal interphalangeal joint

Tyrnenopoulou

Diakakis

Karayannopoulou

et al. 2016

Veterinary Quarterly

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Background: Regenerative medicine has become one of the most promising therapies of equine osteoarthritis. Platelet lysate (PL) is rich in bioactive proteins and growth factors that play a crucial role in tissue healing. Objective: To evaluate the efficacy of intra-articularly injected autologous PL in equine athletes with naturally occurring osteoarthritis. Animals and methods: Fifteen warmblood geldings aged 8À19 years with osteoarthritis of the distal interphalangeal joint were included in this study. They were randomly divided into two groups; 10 horses received intra-articular injections of PL and 5 of normal saline (controls). Before treatment, platelet-derived growth factor (PDGF) levels in basal plasma and prepared PL were estimated. Each joint was injected twice within a three-week period. Lameness was evaluated using the American Association of Equine Practitioners grading system, before treatment and 10 days after each intra-articular injection. Horses were examined fortnightly for one year. Radiographic examination was performed six months post-treatment. The generalized estimating equation test was used for statistical analysis. Results: Acceptable levels of PDGF were detected in PLs (mean § SD: 258.0 § 52.3 pg/ml). The majority of horses (9/10) responded positively to PL treatment presenting lower lameness grades (p < 0.0005) compared to controls 10 days after the second injection, and returned to normal athletic activity. Radiographs revealed no changes in osteoarthritis lesions six months after treatment. One year post-injections, however, all horses relapsed to their initial degree of lameness. Conclusion: Intra-articularly injected autologous PL is an efficient method for temporarily managing osteoarthritis of the distal interphalangeal joint in athletic horses.

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Section: Discussionmentioning

confidence: 53%

Section: Discussionmentioning

confidence: 91%

Section: Introductionmentioning

confidence: 99%

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Evaluation of intra-articular injection of autologous platelet lysate (PL) in horses with osteoarthritis of the distal interphalangeal joint

Tyrnenopoulou

Diakakis

Karayannopoulou

et al. 2016

Veterinary Quarterly

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“…Na medicina humana, o uso do PRP tem apresentado efeitos positivos em cirurgias plásticas (VEDRAMIN et al, 2006), ortopédicas (MISHRA & PAVELKO, 2006), e também no tratamento de osteoartrite (SANCHEZ et al, 2012). Entretanto, na medicina veterinária equina, o uso do PRP é mais recente com sua utilização descrita no tratamento de feridas (CARTER et al, 2003), tendinites e desmites (MAIA, 2008;SUTTER et al, 2008), osteoartrite (CARMONA et al, 2007), e na cicatrização de fraturas (CARMONA & LOPEZ, 2011).…”

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Avaliação de sete protocolos para obtenção de plasma rico em plaquetas na espécie equina

et al. 2013

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“…Já no grupo tratado, 70% (21/30) voltaram ao nível atlético prévio e apenas 9,5% (2/21) voltaram a apresentar a lesão. Carmona et al (2007) utilizando concentrado de plaquetas no tratamento de OA nas articulações femorotibial, metacarpofalangeana, e do tarso observaram melhora no grau de claudicação e redução da efusão articular.…”

Section: O Emprego Dos Derivados Sanguíneos Nas Lesões Osteoarticularesunclassified

Uso do soro autólogo condicionado e do plasma rico em plaquetas na terapia ortopédica de equinos

et al. 2014

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ResumoAs lesões musculoesqueléticas que ocorrem durante a prática esportiva em equinos são debilitantes e demandam um longo período de tratamento e reabilitação, para muitas vezes obter-se após o tratamento apenas um tecido cicatricial, predispondo à recidiva. Em busca de terapias mais efetivas e da reparação tecidual de melhor qualidade, tem sido estudada a utilização de derivados sanguíneos, como plasma rico em plaquetas e soro autólogo condicionado. Apesar de ambos serem considerados hemoderivados, o soro autólogo condicionado e o plasma rico em plaquetas são produtos distintos com indicações totalmente diferentes para seu uso. Em lesões tendíneas e ligamentares o plasma rico em plaquetas apresenta resultado promissor em estudos clínicos e experimentais. Nas lesões osteoarticulares estes resultados são obtidos tanto com o soro autólogo condicionado como com o plasma rico em plaquetas. A presente revisão tem como objetivo apresentar estudos clínicos e experimentais (in vivo e in vitro) na espécie equina, que auxiliem na escolha do melhor hemoderivado a ser utilizado frente às diferentes lesões musculoesqueléticas. Palavras-chave: Plasma rico em plaquetas, soro autólogo condicionado, tendão, ligamento, articulação, músculo AbstractMusculoskeletal injuries that occur in horses during sports activities are often disabling and require a long period of treatment and rehabilitation, most resulting in scar tissue, predisposing to recurrence. In search of more effective therapies and tissue regeneration, studies have been carried out with blood derivatives -platelet rich plasma and autologous conditioned serum. In spite of both being bloodderived therapies, platelet rich plasma and autologous conditioned serum are distinct products, with equally distinct indications for their use. Platelet rich plasma shows promising results in ligament and tendon injuries in clinical and experimental trials. This occurs also in osteoarticular lesions with both hemoderivates, autologous conditioned serum and platelet rich plasma. This review aims to present clinical and experimental studies (in vivo and in vitro) in the equine species, as an aid for an appropriate therapeutic choice, when hemoderivates are considered for treatment of musculoskeletal lesions.

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Autologous Platelet Concentrates as a Treatment of Horses with Osteoarthritis: A Preliminary Pilot Clinical Study

Cited by 85 publications

References 7 publications

Evaluation of intra-articular injection of autologous platelet lysate (PL) in horses with osteoarthritis of the distal interphalangeal joint

Evaluation of intra-articular injection of autologous platelet lysate (PL) in horses with osteoarthritis of the distal interphalangeal joint

Avaliação de sete protocolos para obtenção de plasma rico em plaquetas na espécie equina

Uso do soro autólogo condicionado e do plasma rico em plaquetas na terapia ortopédica de equinos

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