Autologous platelet-rich plasma (PRP) effect on intervertebral disc restoration: an experimental rabbit model

Gelalis, Ioannis D.; Christoforou, Georgios; Charchanti, Antonia; Gkiatas, Ioannis; Pakos, Emilios E.; Papadopoulos, Dimitrios V.; Ploumis, Avraam; Korompilias, Anastasios V.

doi:10.1007/s00590-018-2337-1

Cited by 14 publications

(7 citation statements)

References 21 publications

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“…On the other hand, driven by electronic information technology, the use of computer technology to assist medical image analysis can not only improve the efficiency of radiologists' analysis and diagnosis but also improve their accuracy [4]. erefore, computer-aided detection and diagnosis are becoming a cross-research field that has received increasing attention [5][6][7]. With the rapid development of medical digital equipment and the introduction of a large number of medical equipment in hospitals, hospitals store a large amount of medical image information about patients, which provides a rich data source for data mining of medical images.…”

Section: Medical Image and Medical Information Data Miningmentioning

confidence: 99%

[Retracted] Role of Platelet‐Rich Plasma Gel in Promoting Wound Healing Based on Medical Images of Wounds

Liu

et al. 2022

Contrast Media & Molecular Imaging

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A wound is the pathological change of soft tissue under normal skin caused by various factors, such as collision, contusion, hot crush, avulsion, corrosive chemicals, operations, excessive wound tension after operations, local pressure that cannot be relieved for a long time, liquid immersion, local infection, and rejection reactions caused by allogeneic substances. e skin itself or its underlying soft tissue loses its integrity and continuity, thus losing its normal physiological function. Medical image analysis is a medical term that refers to the interdisciplinary fields of integrated medical imaging, artificial intelligence, digital image processing and analysis, mathematical modeling, and numerical algorithms. According to the time of wound formation, they can be divided into acute and chronic wounds. e common acute wounds include lacerations caused by trauma, surgical incisions, burns, and donor sites formed after skin graft operations.is article mainly studies the role of platelet-rich plasma gel nanocomposites in promoting wound healing. It is proven that ptt-rich plasma gel can significantly promote tissue repair and regeneration and accelerate wound healing in patients with severe burns. e atomic number of the nanocomposite has a better treatment effect on the nanoparticle approach. In this paper, chitosan nanocomposite membrane, nanocomposite algorithm, and the calculation method of enthalpy of formation of high alloy nanomaterials were used to study the role of ptt-rich plasma gel combined chitosan nanocomposite membrane loaded bone marrow stromal cells in promoting wound healing, and its effects were applied to the repair of special site burns, special burns, and different age burns. Good wound repair benefits from the correct treatment of the wound, which directly affects the stability and development of the internal environment. e difference in healing time between the two groups was statistically significant, and the recovery time of the PRP group was 0.001 less than that of the control group. e results showed that the wound healing time of the PRP group was significantly shorter than that of the control group (P < 0.05); after treatment, the content of VEGF in the wound tissue of the two groups increased, especially in the PRP group; the effective rate of the PRP group was 75.0%, which was higher than 68.8% of the control group. It can play an important role in the regulation of expression and the pathophysiological process of wound healing.

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Section: Medical Image and Medical Information Data Miningmentioning

confidence: 99%

[Retracted] Role of Platelet‐Rich Plasma Gel in Promoting Wound Healing Based on Medical Images of Wounds

Liu

et al. 2022

Contrast Media & Molecular Imaging

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“…The regeneration effect of PRP on IVD cells has been confirmed using in vitro in vivo studies. An animal study reported that an injured IVD model treated with PRP immediately after injury resulted in the retainment of morphologic features, fewer inflammatory cytokines, and retarded IVD degeneration [41][42][43]. Furthermore, many clinical trials have a significant reduction in pain and improvement in physical function of DLBP at different time points after treatment with PRP intradiscal injection.…”

Section: Discussionmentioning

confidence: 99%

Intradiscal Autologous Platelet‐Rich Plasma Injection for Discogenic Low Back Pain: A Clinical Trial

Zhang

Liu

Gong

et al. 2022

BioMed Research International

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Background. Platelet-rich plasma (PRP) contains high concentrations of growth factors and cytokines and may promote healing and tissue formation and exert anti-inflammatory effects. PRP has been shown to improve intervertebral disc degeneration in vivo and in vitro. This study is aimed at evaluating the effectiveness of autologous PRP on discogenic low back pain (DLBP) at 48 weeks postinjection in patients who received a single intradiscal injection. Methods. All patients received a single intradiscal injection of PRP in a prospective trial. The pain scores, lumbar function, and adverse events were assessed at 1 week, 4 weeks, 8 weeks, 12 weeks, 24 weeks, and 48 weeks postinjection and compared to the preinjection values (0 weeks). Results. Data were analysed from 31 patients with a 94% follow-up rate. Compared to preinjection, pain and lumbar function were significantly improved, and there were significant differences ( P < 0.05 ) over the 48-week follow-up. Twenty-two (71%) patients were classified as successes after the intradiscal injection of PRP. One patient received surgery at two weeks postinjection due to intervertebral discitis. Conclusions. Intradiscal injection of PRP can significantly relieve pain sensation and improve lumbar function in patients with DLBP over a 48-week follow-up period. Further randomized controlled clinical trials are needed to assess the effects of this injection therapy.

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“…After that, autologous PRP growth factors were injected using a 27-gauge needle. After 6 weeks, intradiscal treatment of PRP in IVDD incited the maintenance of basic morphological characteristics with the restoration of the disc after needle puncture injury . Later, the IVDD model was developed in New Zealand rabbits by inducing annular puncture and the blend of PRP and ADSCs injected.…”

Section: Methods Of Developing In Vivo Ivd Injury Modelmentioning

confidence: 99%

Evaluation of Tissue Engineering Approaches for Intervertebral Disc Regeneration in Relevant Animal Models

Malli

Kumbhkarn

Dewle

et al. 2021

ACS Appl. Bio Mater.

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Translation of tissue engineering strategies for the regeneration of intervertebral disc (IVD) requires a strong understanding of pathophysiology through the relevant animal model. There is no relevant animal model due to differences in disc anatomy, cellular composition, extracellular matrix components, disc physiology, and mechanical strength from humans. However, available animal models if used correctly could provide clinically relevant information for the translation into humans. In this review, we have investigated different types of strategies for the development of clinically relevant animal models to study biomaterials, cells, biomolecular or their combination in developing tissue engineering-based treatment strategies. Tissue engineering strategies that utilize various animal models for IVD regeneration are summarized and outcomes have been discussed. The understanding of animal models for the validation of regenerative approaches is employed to understand and treat the pathophysiology of degenerative disc disease (DDD) before proceeding for human trials. These animal models play an important role in building a therapeutic regime for IVD tissue regeneration, which can serve as a platform for clinical applications.

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Autologous platelet-rich plasma (PRP) effect on intervertebral disc restoration: an experimental rabbit model

Cited by 14 publications

References 21 publications

[Retracted] Role of Platelet‐Rich Plasma Gel in Promoting Wound Healing Based on Medical Images of Wounds

[Retracted] Role of Platelet‐Rich Plasma Gel in Promoting Wound Healing Based on Medical Images of Wounds

Intradiscal Autologous Platelet‐Rich Plasma Injection for Discogenic Low Back Pain: A Clinical Trial

Evaluation of Tissue Engineering Approaches for Intervertebral Disc Regeneration in Relevant Animal Models

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