Autologous Tooth Graft after Endodontical Treated Used for Socket Preservation: A Multicenter Clinical Study

Abstract

The aim of the study was to evaluate the tooth extracted use as autologous tooth graft after endodontic root canal therapies used for socket preservation. To this purpose, the Tooth Transformer shredding and decontamination machine has been used. The graft obtained in this way, was inserted at the time of the extraction or at a second surgery altogether with the chosen regenerative therapy. This clinical trial enrolled patients with post-estractive defects requiring the restoration bone dimension and shape in the maxillary and mandibular zone. In addition, 98 patients with 119 extraction sockets were enrolled across 10 standardized centers. An innovative preparation method, using the dedicated automated device Tooth Transformer, able to transform autologous teeth in suitable grafting material, has been used. The extracted tooth was cleaned and treated using a Tooth Transformer and made a socket preservation. Thirteen Biopsies were realized to analyze the histologic outcomes at the average time of four months to demonstrate that the autologous tooth graft made from root after endodontic therapy should be used in human bone regeneration as graft for dental implant placement.

Autologous Deciduous Tooth-Derived Material for Alveolar Ridge Preservation: A Clinical and Histological Case Report

“…There are several papers about the use of tooth materials (dentin and enamel) as bone substitutes, acknowledging the advantage of being available after tooth extraction, thus avoiding other surgical procedures to be grafted (as it happens for the block graft from the mandibular ramus, for example) [10,16,17].…”

Alveolar Socket Preservation with Different Autologous Graft Materials: Preliminary Results of a Multicenter Pilot Study in Human

“…From these scientific considerations, and from several studies of dental tissue embryology, the first aim of research should be to verify if the extracted tooth, currently considered waste material [21][22][23], could be used as graft material in alveolar socket preservation procedures [24]. Furthermore, the behavior of the endodontically treated tooth in bone regeneration procedures should be determined, as well as if the tooth, properly cleaned after endodontic treatment, could be used in these surgical procedures [25,26].…”

Innovative Concepts and Recent Breakthrough for Engineered Graft and Constructs for Bone Regeneration: A Literature Systematic Review

“…The authors state that the success of the implant after bone regeneration was 99.1%, and the time it took for bone healing to be ready for implant was four months. The demineralization and decontamination performed by the solution does not eliminate BMP-2 and collagen [ 130 , 131 ]. The same author continued his research by using the Tooth Transformer on sinus lift with the same technique on a demineralized and granulated tooth [ 98 ].…”

“…If the dental matrix is processed in the right way, it has osteoinductive properties determined by the morphogenetic proteins BMPs, which are contained in physiological quantities in the tooth. The tooth crushed with Tooth Transformer (TT) seems to preserve these osteoinductive properties with a partial demineralization of the dental matrix without damaging its structure, offering a graft in 400–800 mm particles that are easy to handle during surgery [ 98 , 123 , 125 , 128 , 130 , 131 , 132 , 134 ]. The demineralized dental matrix has a faster resorption time than mineralized dentin as biodegradation is almost impossible for large particles with high crystalline.…”