Automated criterion-based analysis for Cole parameters assessment from cerebral neonatal electrical bioimpedance spectroscopy measurements

Abstract

Hypothermia has been proven as an effective rescue therapy for infants with moderate or severe neonatal hypoxic ischemic encephalopathy. Hypoxia-ischemia alters the electrical impedance characteristics of the brain in neonates; therefore, spectroscopic analysis of the cerebral bioimpedance of the neonate may be useful for the detection of candidate neonates eligible for hypothermia treatment. Currently, in addition to the lack of reference bioimpedance data obtained from healthy neonates, there is no standardized approach established for bioimpedance spectroscopy data analysis. In this work, cerebral bioimpedance measurements (12 h postpartum) in a cross-section of 84 term and near-term healthy neonates were performed at the bedside in the post-natal ward. To characterize the impedance spectra, Cole parameters (R(0), R(∞), f(C) and α) were extracted from the obtained measurements using an analysis process based on a best measurement and highest likelihood selection process. The results obtained in this study complement previously reported work and provide a standardized criterion-based method for data analysis. The availability of electrical bioimpedance spectroscopy reference data and the automatic criterion-based analysis method might support the development of a non-invasive method for prompt selection of neonates eligible for cerebral hypothermic rescue therapy.

Improved Sensing Pulses for Increased Human Head Depth Measurement Sensitivity With Electrical Impedance Spectroscopy

“…Optimization of depth sensitivity in EIS measurement using the dual-energy SGF excitation pulses also has the potential to help develop proposed future point-of-care clinical applications, such as ICH and stroke detection [7], [8], [10], [46], [47] as well as noninvasive assessment of brain tumors [48], arteriovenous malformations, and radiation injury [49], cervical intraepithelial neoplasia [50], perinatal hypoxia [51] and asphyxia [52], [53], thyroid nodules classification [54], and functional electrical stimulation efficacy [55], epilepsy [56], [57], and general brain function [58]. …”

Interference of heart and transcutaneous oxygen monitoring in the measurement of bioelectrical impedance analysis in preterm newborns

“…3 Currently, in addition to the limited data available on BIA in newborns, mainly preterm ones, there is no consensus on the methodological standardization of this exam for this population. 4 For instance, it has been suggested that being attached to a monitoring wire precludes the performance of the BIA. However, the continuous monitoring of several physiological parameters is required to maintain the safety of newborns in intensive care.…”

Development of a Stair-Step Multifrequency Synchronized Excitation Signal for Fast Bioimpedance Spectroscopy

“…The spectra of MLS and chirp pulse both have a continuous plateau envelope where most of the energy is concentrated. But in most BIS applications, only a discrete set of frequencies is required to fit the impedance data to a model like Cole equation [20], and BIS devices usually need to perform measurements at several to tens of isolated frequencies (usually with large frequency intervals) over a wide range of frequencies (often from 5 kHz to 1 MHz) [21]. Consequently, wideband excitation signal whose energy is distributed mainly in finite frequency points with large frequency spacing is ideal for BIS measurements.…”