Automated design of microfluidics-based biochips: connecting biochemistry to electronics CAD

Chakrabarty, Krishnendu

doi:10.1109/dtis.2006.1708725

International Conference on Design and Test of Integrated Systems in Nanoscale Technology, 2006. DTIS 2006. 2006

DOI: 10.1109/dtis.2006.1708725

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Automated design of microfluidics-based biochips: connecting biochemistry to electronics CAD

Krishnendu Chakrabarty¹

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2014

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Design and characterization of a lab-on-chip for continuous bioluminescent measurements of ATP

Feng

Dong

2014

2014 IEEE International Symposium on Medical Measurements and Applications (MeMeA)

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A novel multifunctional two-sides silicon lab-onchip (LOC) was designed and fabricated for providing a highefficient long-term continuous analysis platform of measuring the concentration of adenosine 5'-triphosphate (ATP) based on bioluminescence. This lab-on-chip mainly consists of Y shape internal ribbed micro mixers, T-junction droplet generators， different kinds of spiral time delay channels (TD-Cs) and the chambers. Enzyme solutions and ATP were separately injected into the chip at different flow rates through 3 inlet ports. Due to the advantage of Segmented Flow Analysis (SFA), it was introduced and applied with the T-junction droplet generators in this paper, and thus oxygen was injected into the central of the bottom surface through another main inlet periodically. Numerical investigations prove that combing with SFA and Tjunction droplet generator is stable to transport the sample; micro mixer can achieve an outstanding mixing efficiency in a small space; the detection of ATP standard solution at optimal conditions was successful, keeping a good linearity between the concentration with the intensity of light during the range from 10 −5 mol /ml to 10 −9 mol/ml.

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Design and characterization of a lab-on-chip for continuous bioluminescent measurements of ATP

Feng

Dong

2014

2014 IEEE International Symposium on Medical Measurements and Applications (MeMeA)

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Automated design of microfluidics-based biochips: connecting biochemistry to electronics CAD

Cited by 1 publication

References 57 publications

Design and characterization of a lab-on-chip for continuous bioluminescent measurements of ATP

Design and characterization of a lab-on-chip for continuous bioluminescent measurements of ATP

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