Automated Fecal Biomarker Profiling - a Convenient Procedure to Support Diagnosis for Patients with Inflammatory Bowel Diseases

Kraemer, Anette; Булгакова, Т. В.; Schukina, Oksana; Харитидис, А.М.; Харитонов, А. Г.; Korostovtseva, Ekaterina; Hammar, Friederike; Bang, Holger; Лапин, С. В.

doi:10.7754/clin.lab.2020.191029

Cited by 5 publications

(4 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Automated ELISA tests are currently available allowing to analyze the samples at any time, even individually. Importantly, the diagnostic accuracy of these tests is equivalent to the traditional ELISA method 33–40 . Recently, point of care rapid tests and home tests have been developed.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

International consensus on methodological issues in standardization of fecal calprotectin measurement in inflammatory bowel diseases

et al. 2021

View full text Add to dashboard Cite

Background: Fecal calprotectin (FC) is a non-invasive marker of gut inflammation which is frequently used to guide therapeutic decisions in patients with inflammatory bowel diseases (IBD). Each step of FC measurement can influence the results, leading to misinterpretations and potentially impacting the management of IBD patients. To date, there is high heterogeneity between FC measurements and no current method is universally accepted as a standard.Aims: Our aim was to provide clear position statementsabout the pre-analytical and the analytical phases of FC measurement to homogenize FC levels and to minimize variability and risk of misinterpretation through aninternational consensus.Materials & Methods: Fourteen physicians with expertise in the field of IBD and FC from 11 countries attended a virtual international consensus meeting on July 17th, 2020. A systematic literature was conducted and the literature evidence was shared and discussedamong the participants. Statements were formulated, discussed, and voted. Statements were considered approved if all participants agreed.Results: Nine statements were formulated and approved. Based on the available evidence, quantitative tests should be preferred for measuring FC. Furthermore, FC measurement, if possible, should always be performed with the same method and factors influencing FC levels should be taken into account when interpreting the results.Discussion: FC has an increasingly important role in the management of patients with IBD. However, large multicenter studies should be conducted to define the reproducibility and to confirm the diagnostic accuracy of the available FC tests.This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

show abstract

Section: Resultsmentioning

confidence: 99%

“…Importantly, the diagnostic accuracy of these tests is equivalent to the traditional ELISA method. [33][34][35][36][37][38][39][40] Recently, point of care rapid tests and home tests have been developed. POC tests use specific lateral flow immunoassays.…”

Section: Statementmentioning

confidence: 99%

International consensus on methodological issues in standardization of fecal calprotectin measurement in inflammatory bowel diseases

et al. 2021

View full text Add to dashboard Cite

show abstract

“…The summary sensitivity was 93% (95%CI: 85-97) and specificity 96% (95%CI: 79-99%) for IBD diagnosis [53]. Rapid fecal calprotectin tests have been recently shown comparable to the enzyme-linked immunosorbent assay [54,55], but they are not widely available.…”

Section: Barbara Et Al Ibs Guidelinesmentioning

confidence: 99%

Italian guidelines for the management of irritable bowel syndrome

Barbara

Cremon

Bellini

et al. 2023

Digestive and Liver Disease

View full text Add to dashboard Cite

“…Одним із важливих маркерів є фекальний кальпротектин (КП) -надійний неінвазивний критерій запалення слизової оболонки при ЗЗК [4,8]. КП може розглядатися у якості біомаркера, що засвідчує про активацію, руйнування та загибель нейтрофільних клітин і, меншою мірою, -моноцитів і активованих макрофагів [1,5]. У клінічній практиці тест з фекальним КП може використовуватися як для контролю перебігу ЗЗК, так і у якості біомаркера для раннього виявлення рецидивів захворювання [2,9].…”

unclassified

Biochemical Markers of Non-Specific Ulcerative Colitis and Crown Diseases: C-Reactive Protein, Fecal Calprotectin, Association With Disease Severity

Shorikova¹

2020

Clin. and experim. pathol.

View full text Add to dashboard Cite

Automated Fecal Biomarker Profiling - a Convenient Procedure to Support Diagnosis for Patients with Inflammatory Bowel Diseases

Cited by 5 publications

References 0 publications

International consensus on methodological issues in standardization of fecal calprotectin measurement in inflammatory bowel diseases

International consensus on methodological issues in standardization of fecal calprotectin measurement in inflammatory bowel diseases

Italian guidelines for the management of irritable bowel syndrome

Biochemical Markers of Non-Specific Ulcerative Colitis and Crown Diseases: C-Reactive Protein, Fecal Calprotectin, Association With Disease Severity

Contact Info

Product

Resources

About