Automated ICP-MS method to measure bromine, chlorine, and iodine species and total metals content in drinking water

Quarles, C. Derrick; Toms, Andrew; Smith, R. A. D.; Sullivan, Patrick; Bass, David; Leone, John P.

doi:10.1016/j.talo.2020.100002

Cited by 9 publications

(4 citation statements)

References 34 publications

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“…Whereas the above techniques are predominantly applied to analyze organic molecules, tools are available for accurate identification and quantification of inorganic species. For determination of inorganic anions beyond the basic elemental identity/quantity information, ion chromatography may be employed with a conductivity detector for anion detection. , More selective approaches for anions include ion chromatography coupled with ICP/MS, , halogen anion speciation ICP/MS, and ion pairing LC-ICP/MS for nonhalogen anions (e.g., arsenate vs dimethylarsenic acid ,, ). Alternatively, volatile/semivolatile organometallics such as methylmercury , may be detected with GC-ICP/MS.…”

Section: Chemical Analysismentioning

confidence: 99%

“…For determination of inorganic anions beyond the basic elemental identity/quantity information, ion chromatography may be employed with a conductivity detector for anion detection. 141,142 More selective approaches for anions include ion chromatography coupled with ICP/MS, 143,144 halogen anion speciation ICP/MS, 145 and ion pairing LC-ICP/MS for nonhalogen anions (e.g., arsenate vs dimethylarsenic acid 144,146,147 ). Alternatively, volatile/semivolatile organometallics such as methylmercury 148,149 the analyst does not need to identify, quantify, or report for toxicological risk assessment.…”

Section: ■ Extractionmentioning

confidence: 99%

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Chemical Characterization and Non-targeted Analysis of Medical Device Extracts: A Review of Current Approaches, Gaps, and Emerging Practices

Sussman

Öktem

Isayeva

et al. 2022

ACS Biomater. Sci. Eng.

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The developers of medical devices evaluate the biocompatibility of their device prior to FDA’s review and subsequent introduction to the market. Chemical characterization, described in ISO 10993-18:2020, can generate information for toxicological risk assessment and is an alternative approach for addressing some biocompatibility end points (e.g., systemic toxicity, genotoxicity, carcinogenicity, reproductive/developmental toxicity) that can reduce the time and cost of testing and the need for animal testing. Additionally, chemical characterization can be used to determine whether modifications to the materials and manufacturing processes alter the chemistry of a patient-contacting device to an extent that could impact device safety. Extractables testing is one approach to chemical characterization that employs combinations of non-targeted analysis, non-targeted screening, and/or targeted analysis to establish the identities and quantities of the various chemical constituents that can be released from a device. Due to the difficulty in obtaining a priori information on all the constituents in finished devices, information generation strategies in the form of analytical chemistry testing are often used. Identified and quantified extractables are then assessed using toxicological risk assessment approaches to determine if reported quantities are sufficiently low to overcome the need for further chemical analysis, biological evaluation of select end points, or risk control. For extractables studies to be useful as a screening tool, comprehensive and reliable non-targeted methods are needed. Although non-targeted methods have been adopted by many laboratories, they are laboratory-specific and require expensive analytical instruments and advanced technical expertise to perform. In this Perspective, we describe the elements of extractables studies and provide an overview of the current practices, identified gaps, and emerging practices that may be adopted on a wider scale in the future. This Perspective is outlined according to the steps of an extractables study: information gathering, extraction, extract sample processing, system selection, qualification, quantification, and identification.

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Section: Chemical Analysismentioning

confidence: 99%

Section: ■ Extractionmentioning

confidence: 99%

Chemical Characterization and Non-targeted Analysis of Medical Device Extracts: A Review of Current Approaches, Gaps, and Emerging Practices

Sussman

Öktem

Isayeva

et al. 2022

ACS Biomater. Sci. Eng.

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“…Therefore, the sensitive detection of iodine ions has become increasingly important in these fields [ 8 ]. Traditional techniques have been employed for iodine detection [ 9 , 10 , 11 , 12 ], but their application is limited due to the need for skilled technicians and high costs. Consequently, there is a pressing need to design and synthesize highly specific sensors with superior performance to meet practical application requirements.…”

Section: Introductionmentioning

confidence: 99%

A “Pincer” Type of Acridine–Triazole Fluorescent Dye for Iodine Detection by Both ‘Naked-Eye’ Colorimetric and Fluorometric Modes

Yu,

Jiang,

Mou

et al. 2024

Molecules

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Iodine, primarily in the form of iodide (I−), is the bioavailable form for the thyroid in the human body. Both deficiency and excess intake of iodide can lead to serious health issues, such as thyroid disease. Selecting iodide ions among anions has been a significant challenge for decades due to interference from other anions. In this study, we designed and synthesized a new pincer-type acridine–triazole fluorescent probe (probe 1) with an acridine ring as a spacer and a triazole as a linking arm attached to two naphthol groups. This probe can selectively recognize iodide ions in a mixed solvent of THF/H2O (v/v, 9/1), changing its color from colorless to light yellow, making it suitable for highly sensitive and selective colorimetric and fluorescent detection in water systems. We also synthesized another molecular tweezer-type acridine–triazole fluorescent probe (probe 2) that exhibits uniform detection characteristics for iodide ions in the acetonitrile system. Interestingly, compared to probe 2, probe 1 can be detected by the naked eye due to its circulation effect, providing a simple method for iodine detection. The detection limit of probe 1 is determined to be 10−8 mol·L−1 by spectrometric titration and isothermal titration calorimetry measurements. The binding stoichiometry between probe 1 and iodide ions is calculated to be 1:1 by these methods, and the binding constant is 2 × 105 mol·L−1.

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“…For determination of iodine in food samples, iodine can be isolated/extracted or sample matrix must be treated before analysis. Several methods have been used such as inductively-coupled plasma/mass spectrometry (ICP-MS) method [27], spot-kits versus titration method [5], solid phase colorimetric, iodometric titration method [28], optical methods using various polymer materials containing polyvinyl pyrrolidone as solid phase extractant [29], spectrophotometric kinetic method [30], and paper-based analytical devices based on colorimetric method [1,4,8,[13][14][15][16].…”

Section: Chapter I Introductionmentioning

confidence: 99%

Simple headspace device for determination of volatile compounds in food and drug samples

Meesuwan¹

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This work presented a simple alternative method for simultaneous extraction and determination of volatile compounds in complex matrix samples by combining headspace technique with paper based colorimetric method. The paper loaded with colorimetric reagent that was attached to the liner of the vial cap making a simple headspace device for direct detection of the semi-volatile and volatile compounds in headspace extraction mode. A sample was placed in a vial sealed with the paper-based headspace device. The method was tested for determination of volatile compound using ethanol as a model and semi-volatile compound using iodine as a model in complex matrix samples. Ethanol volatilized and reacted with chromic acid reagent, which was generated by mixing sodium or potassium dichromate with sulfuric acid, on the paper. The orange color of solution containing dichromate (VI) change to green solution containing chromium (III) ions. Iodine was volatilized by using oxidizing agent and react with starch reagent on the paper. The colorless of starch solution change to dark blue color of iodine-starch solution. The image of the paper was taken by the scanner for determination of iodine and by digital camera for determination of alcohol. The images were processing by ImageJ software in RGB mode and the blue intensity was taken for quantification. For determination of alcohol, the sample was heated at 40 o C for 5 min. The method was applied for determination of alcohol content in drug (i.e., stomachic mixtures and Salol et menthol mixture), and beverage sample (i.e., beer). The linear calibration ranged from 0-7 % (v/v) of ethanol with R2 > 0.97 was obtained. The recovery of 94-120% and the relative standard deviation of less than 3% were achieved. For determination of iodine, the treatment of spiked egg sample with 0.4 g/mL TCA was heated at 50 o C for 15 min. The linear calibration ranged from 0-100 ppm of iodine with R2 > 0.98 was obtained. The recovery of 93% and the relative standard deviation of less than 2% were achieved.

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Automated ICP-MS method to measure bromine, chlorine, and iodine species and total metals content in drinking water

Cited by 9 publications

References 34 publications

Chemical Characterization and Non-targeted Analysis of Medical Device Extracts: A Review of Current Approaches, Gaps, and Emerging Practices

Chemical Characterization and Non-targeted Analysis of Medical Device Extracts: A Review of Current Approaches, Gaps, and Emerging Practices

A “Pincer” Type of Acridine–Triazole Fluorescent Dye for Iodine Detection by Both ‘Naked-Eye’ Colorimetric and Fluorometric Modes

Simple headspace device for determination of volatile compounds in food and drug samples

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