Automated production of [11C]butyrate for keto body PET imaging

Automated production of 11C‐labeled carboxylic acids and esters via “in‐loop” 11C‐carbonylation using GE FX synthesis modules

“…4 It is typically produced by the proton bombardment of the N 2 gas according to 14 N (p,α) 11 C nuclear reaction. This reaction may be conducted using a cyclotron in the presence of O 2 ($0.5-1%) to produce [ 11 C]CO 2 , a routinely used carbon-11 synthon that can be used directly, 5,6 or derivatized to produce various carbon-11 labeled synthons. 7,8 For example, [ 11 C]CO can be obtained via partial reduction of [ 11 C]CO 2 over a Mo, Zn, or activated charcoal surface 9,10 and has found excellent utility in medical imaging.…”