Automated sample preparation for drugs in plasma using a solid-phase extraction workstation

Improved Intestinal Transport of PD 158473, an N-methyl-d-Aspartate (NMDA) Antagonist, by Involvement of Multiple Transporters

“…At specified time periods (0, 5, 10, 15, 30, 60, 120, 180, 240, 720, and 1440 min), blood was collected into heparinized tubes from a cannula previously placed in the jugular vein. Samples were extracted by solid‐phase extraction on RapidTrace® and analyzed by LC/MS/MS as reported elsewhere 8…”

Method development for the influence of matrix on selected organochlorine pesticide residue analysis in surface water by GC-MS

“…Sample preparation is the most tedious and time consuming step and a possible source of errors (Huck and Bonn [13]; He et al [14]). Automated solid phase extraction was employed as it is more rapid, precise and accurate compared to the conventional manual SPE extraction (Parker et al [15]; Rossi and Zhang [16]). …”

Automated high throughput ADME assays for metabolic stability and cytochrome P450 inhibition profiling of combinatorial libraries

“…This approach is often seen in biological high throughput screening labs and relies heavily on complex automated systems, robotics and engineering specialists resulting in significant capital investment [21]. The second involves the use of individual workstations, an approach that has been benchmarked in current DMPK departments [22,23]. This approach, while effective, is highly dependent on user intervention for the transfer of materials and reagents.…”