Automated three-dimensional finite element modeling of bone

Keyak, Joyce H.; Meagher, Jim; Skinner, Harry B.; Mote, C. D.

doi:10.1016/0021-9290(87)90197-7

Cited by 17 publications

(23 citation statements)

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“…In particular, studies at the scale of 5-8 mm could be particularly useful for testing the idea that changes in bone microarchitecture and/or tissue material properties are responsible for any clinically relevant changes in bone biomechanical performance relative to density. For example, if it turns out that a particular treatment does not change bone quality at the scale of 5-8 mm, then attention can be focused on analysis of bone quality at higher physical scales, which should be feasible using current radiological techniques combined with finite element analysis [44,[60][61][62][63][64][65] or with whole bone mechanical testing. In this way a more complete picture of how characteristics of bone might explain discrepancies between aBMD and fracture incidence can be achieved.…”

Section: What Do We Know About Trabecular Bone Quality?mentioning

confidence: 99%

A biomechanical perspective on bone quality

Hernandez¹,

Keaveny²

2006

Bone

273

183

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Observations that dual-energy x-ray absorptiometry (DXA) measures of areal bone mineral density cannot completely explain fracture incidence after anti-resorptive treatment have led to renewed interest in bone quality. Bone quality is a vague term, but generally refers to the effects of skeletal factors that contribute to bone strength but are not accounted for by measures of bone mass. Since a clinical fracture is ultimately a mechanical event, it follows then that any clinically relevant modification of bone quality must change bone biomechanical performance relative to bone mass. In this perspective, we discuss a framework for assessing the clinically relevant effects of bone quality based on two general concepts: 1) the biomechanical effects of bone quality can be quantified from analysis of the relationship between bone mechanical performance and bone density; and 2) because of its hierarchical nature, biomechanical testing of bone at different physical scales (<1mm, 1mm, 1 cm, etc.) can be used to isolate the scale at which the most clinically relevant changes in bone quality occur. As an example, we review data regarding the relationship between the strength and density in excised specimens of trabecular bone and highlight the fact that it is not yet clear how this relationship changes during aging, osteoporosis development, and anti-resorptive treatment. Further study of new and existing data using this framework should provide insight into the role of bone quality in osteoporotic fracture risk.

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Section: What Do We Know About Trabecular Bone Quality?mentioning

confidence: 99%

A biomechanical perspective on bone quality

Hernandez¹,

Keaveny²

2006

Bone

273

183

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“…In the finite element approach to bone adaptation simulation, the integration of the entries in the coefficient matrix can be a heavy computing task [22,23,26,27]. In the model proposed here, this is alleviated through the introduction of the simpler connectivity matrix and Jacobian matrix [38].…”

Section: Discussionmentioning

confidence: 99%

“…Various computational models have been put forward in the past decades and the methods describing the changing rate of bone density corresponding to strain energy density, with finite element implementation, have become the most popular of them [6,[15][16][17][18][19][20][21][22][23][24][25][26][27][28][29].…”

Section: Introductionmentioning

confidence: 99%

“…The common finite element approach is to take the element densities as the state variables and define elements with either constant or varying densities, then update the material densities for the next step of computation according to the computed strain energy density [22,23,26,27]. With more and more powerful desktop computers and commercial finite element analysis software available, this approach is widely used today.…”

Section: Introductionmentioning

confidence: 99%

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Volume-based non-continuum modeling of bone functional adaptation

Wang

Mondry

2005

Theor Biol Med Model

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Background: Bone adapts to mechanical strain by rearranging the trabecular geometry and bone density. The common finite element methods used to simulate this adaptation have inconsistencies regarding material properties at each node and are computationally demanding. Here, a volumebased, non-continuum formulation is proposed as an alternative. Adaptive processes corresponding to various external mechanical loading conditions are simulated for the femur.

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“…It is a computationally intensive engineering technique that estimates how objects of complex design resist loads . CT imaging is a useful method to gather three-dimensional physiological data such as bone geometry and density in vivo (Keyak et al, 1990). The results of von Mises' stress distribution in a human model of normal mandible showed that the model was reliable (Vollmer et al, 2000).…”

Section: Rabbit: 3d Finite Element Analysismentioning

confidence: 99%