Automated three-dimensional registration and volume rebuilding for wide-field angiographic and structural optical coherence tomography

Abstract

, "Automated three-dimensional registration and volume rebuilding for wide-field angiographic and structural optical coherence tomography," J. Biomed. Opt. Abstract. We propose a three-dimensional (3-D) registration method to correct motion artifacts and construct the volume structure for angiographic and structural optical coherence tomography (OCT). This algorithm is particularly suitable for the nonorthogonal wide-field OCT scan acquired by a ultrahigh-speed swept-source system (>200 kHz A-scan rate). First, the transverse motion artifacts are corrected by the between-frame registration based on en face OCT angiography (OCTA). After A-scan transverse translation between B-frames, the axial motions are corrected based on the rebuilt boundary of inner limiting membrane. Finally, a withinframe registration is performed for local optimization based on cross-sectional OCTA. We evaluated this algorithm on retinal volumes of six normal subjects. The results showed significantly improved retinal smoothness in 3-D-registered structural OCT and image contrast on en face OCTA.

Multi-reference global registration of individual A-lines in adaptive optics optical coherence tomography retinal images

“…Do 7 (2016, master’s thesis, Section 9) found that our method is more robust to fast microsaccadic eye movements than previous 2D strip-wise approaches. 12 , 13 Our method is also simpler than some previous approaches in that it does not require identification of specific features (e.g., blood vessels for feature-based registration 47 – 49 ) or segmentation of particular retinal layers to estimate eye motion, making it readily applicable to raster-scanned OCT images. This consideration should also make our approach more robust to retinal deformation caused by, e.g., edemas or drusen that make both layer segmentation and feature identification more difficult.…”

Optical Coherence Tomography Angiography for Macular Telangiectasia Type 2

“…The principle behind is sequential B-scan images over same retinal location, with subsequent analysis of change in amplitude and phase, inferred as flow of red blood cells in vasculature [3]. This cube scan generates a 3-dimensional image set and its extension provides en-face view of the vasculature at different layers of the retina [4]. Therefore, a flow-based imaging is available on top of the intensity-based B-scan imaging [5].…”

Efficient and high accuracy 3-D OCT angiography motion correction in pathology

“…Some methods additionally allow mosaicing of partially overlapping volumes [23,24], but are limited to alignment in the en face plane. Others allow full 3-D alignment including the axial dimension [21,[25][26][27][28]. A fundamental differentiation between software methods is the underlying scan pattern.…”