Automatic affective processing impairments in patients with deficit syndrome schizophrenia

Strauss, Gregory P.; Allen, Daniel N.; Duke, Lisa A.; Ross, Sylvia; Schwartz, Jason L.

doi:10.1016/j.schres.2008.01.014

Cited by 51 publications

(43 citation statements)

References 53 publications

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“…Contrarily, our results suggest that the weaker recognition of threatening faces in psychotic disorder (e.g., Bediou et al, 2005;Leppänen et al, 2006;Namiki et al, 2007;Pinkham et al, 2014) may have influenced the detection of potential social threat, leading to a lower impact of task-irrelevant angry faces during the attentional task. A previous study used an emotional Stroop task and found that patients with deficit syndrome took longer to name the colour of a neutral word when it was immediately preceded by a negative word, thus revealing difficulties in disengaging attention from unpleasant stimuli (Strauss et al, 2008). Our findings showed greater interference with a positive rather than negative stimuli; this difference in results might be because Strauss et al used words with positive and negative valence rather than face expressions, which are a social stimulus.…”

Section: Discussioncontrasting

confidence: 53%

“…First, view of our small sample size, the results should be interpreted with caution. Future studies should address this issue in larger samples, allowing the manipulation of different variables as state anxiety and symptoms category, namely, the negative sub syndrome (Addington and Addington, 1997;Mitchell and Rossell, 2014;Nieuwenstein et al, 2001;Strauss et al, 2008Strauss et al, , 2011). In the current study, 81.8% of healthy controls had higher education level, while none of the patients achieved this educational level.…”

Section: Discussionmentioning

confidence: 99%

“…Surprisingly, and despite its relevance, few attentional studies on psychotic disorders have used these stimuli. Strauss et al (2008Strauss et al ( , 2011 concluded that psychotic patients with deficit syndrome, i.e., particularly poor outcome and predominately entailing primary and persistent negative symptoms in schizophrenia (see Madeira et al, 2016), have greater difficulty disengaging attention from non-social unpleasant stimuli (disagreeable words), compared to neutral ones. However, Park et al (2011) showed a steeper decline of psychotic patients' performance over time when the task-relevant stimuli were displayed with a happy face (compared to sad and neutral ones).…”

Section: Introductionmentioning

confidence: 99%

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RETRACTED: The effects of perceptual load in processing emotional facial expression in psychotic disorders

Grave

Soares

Morais

et al. 2017

Psychiatry Research

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A B S T R A C TPsychotic disorders are some of the most severe psychiatric conditions. Patients have difficulties in identifying facial expressions and appear to be highly sensitive to the presence of emotional distractors. Yet, no study has investigated whether perceptual load modulates the interference of emotional distractors. Our goal was to test whether psychotic patients were more sensitive to irrelevant emotional stimulus, even when the task demands a high amount of attentional resources. Twenty-two participants with schizophrenia or schizoaffective disorder and twenty-two healthy controls, performed a target letter discrimination task with emotional task-irrelevant stimulus (angry, happy and neutral facial expressions). Target-letters were presented among distrator-letters, which could be similar (low perceptual load) or different (high load); participants should discriminate the target-letter and ignore the facial expression. Results showed that patients were more prone to distraction by task-irrelevant stimulus, especially under high load, suggesting difficulties in attention control. Moreover, in psychotic patients, happy faces caused higher interference with the task, whereas neutral and angry faces resulted in less interference. These findings could provide innovative approaches regarding attentional deficits on social contexts in patients with schizophrenia spectrum disorders.

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Section: Discussioncontrasting

confidence: 53%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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RETRACTED: The effects of perceptual load in processing emotional facial expression in psychotic disorders

Grave

Soares

Morais

et al. 2017

Psychiatry Research

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“…Tests were administered as part of a larger battery that included other neuropsychological measures, computerized tests, and clinical interviews (Duke et al, 2010;Strauss and Allen, 2013;Strauss et al, 2008Strauss et al, , 2010aStrauss et al, , 2011Strauss et al, , 2010bStrauss et al, , 2012Vogel et al, 2013). Diagnostic and symptom interviews occurred prior to neuropsychological testing.…”

Section: Methodsmentioning

confidence: 99%

The evaluation of insufficient cognitive effort in schizophrenia in light of low IQ scores

Whearty

Allen

Lee

et al. 2015

Journal of Psychiatric Research

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“…[40][41][42] Compared to controls, individuals with SCZ and BDP show greater deficits in attention towards the task-relevant dimension in the presence of the task-irrelevant emotional dimension that is an integral part of the stimulus. 15,43,44 A recent study found no difference between SCZ and controls for interference from emotional pictures while maintaining object information. 18 However, in this prior study the distraction was from a separate stimulus rather than an integral dimension of the target stimulus.…”

Section: Introductionmentioning

confidence: 95%

Disconnection Between Amygdala and Medial Prefrontal Cortex in Psychotic Disorders

Mukherjee

Sabharwal

Kotov

et al. 2016

SCHBUL

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Distracting emotional information impairs attention more in schizophrenia (SCZ) than in never-psychotic individuals. However, it is unclear whether this impairment and its neural circuitry is indicative generally of psychosis, or specifically of SCZ, and whether it is even more specific to certain SCZ symptoms (eg, deficit syndrome). It is also unclear if this abnormality contributes to impaired behavioral performance and real-world functioning. Functional imaging data were recorded while individuals with SCZ, bipolar disorder with psychosis (BDP) and no history of psychotic disorders (CON) attended to identity of faces while ignoring their emotional expressions. We examined group differences in functional connectivity between amygdala, involved in emotional evaluation, and sub-regions of medial prefrontal cortex (MPFC), involved in emotion regulation and cognitive control. Additionally, we examined correlation of this connectivity with deficit syndrome and real-world functioning. Behaviorally, SCZ showed the worst accuracy when matching the identity of emotional vs neutral faces. Neurally, SCZ showed lower amygdala-MPFC connectivity than BDP and CON. BPD did not differ from CON, neurally or behaviorally. In patients, reduced amygdala-MPFC connectivity during emotional distractors was related to worse emotional vs neutral accuracy, greater deficit syndrome severity, and unemployment. Thus, reduced amygdala-MPFC functional connectivity during emotional distractors reflects a deficit that is specific to SCZ. This reduction in connectivity is associated with worse clinical and real-world functioning. Overall, these findings provide support for the specificity and clinical utility of amygdala-MPFC functional connectivity as a potential neural marker of SCZ.

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Automatic affective processing impairments in patients with deficit syndrome schizophrenia

Cited by 51 publications

References 53 publications

RETRACTED: The effects of perceptual load in processing emotional facial expression in psychotic disorders

RETRACTED: The effects of perceptual load in processing emotional facial expression in psychotic disorders

The evaluation of insufficient cognitive effort in schizophrenia in light of low IQ scores

Disconnection Between Amygdala and Medial Prefrontal Cortex in Psychotic Disorders

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