“…In the state-of-the-art, much effort is dedicated to recognise the cell nucleus since it is a key part for determining biological structures. Previously, the computer-aided recognition of cell nuclei has been addressed using different techniques such as clustering (Gharipour and Liew, 2015;Chankong et al, 2014;Kothari et al, 2009), segmentation (Mohammed et al, 2013;Palacios and Beltran, 2007;Rogojanu et al, 2010) adaptive active contour (Kang et al, 2015;Hafiane et al, 2008;Zeng et al, 2013), and machine learning (Kancherla and Mukkamala, 2013;Han et al, 2012b;Shir et al, 2007).…”