A new evaluation measure of speech recognition and a decoding strategy for keyword-based open-domain speech understanding are presented. Conventionally, WER (word error rate) has been widely used as an evaluation measure of speech recognition, which treats all words in a uniform manner. In this paper, we define a weighted keyword error rate (WKER) which gives a weight on errors from a viewpoint of information retrieval. We first demonstrate that this measure is more appropriate for predicting the performance of key sentence indexing of oral presentations. Then, we formulate a decoding method to minimize WKER based on Minimum Bayes-Risk (MBR) framework, and show that the decoding method works reasonably for improving WKER and key sentence indexing.