The advancement in the field of machine learning is inextricably linked with the concurrent progress in domain-specific hardware accelerators such as GPUs and TPUs. However, the rapidly growing computational demands necessitated by larger models and increased data have become a primary bottleneck in further advancing machine learning, especially in mobile and edge devices. Currently, the neuromorphic computing paradigm based on memristors presents a promising solution. In this study, we introduce a memristorbased MobileNetV3 neural network computing paradigm and provide an end-to-end framework for validation. The results demonstrate that this computing paradigm achieves over 90% accuracy on the CIFAR-10 dataset while saving inference time and reducing energy consumption. With the successful development and verification of MobileNetV3, the potential for realizing more memristor-based neural networks using this computing paradigm and open-source framework has significantly increased. This progress sets a groundbreaking pathway for future deployment initiatives.