The technological development ongoing in the maritime industry is making the ground for remotely and even autonomously operated vessels in the future. This is a result of increased data collection, processing and inter-connectivity capabilities. The industry is working towards increased safety, improved efficiency of the ship’s operation, improved environmental performance and a more cost-effective shipping. New technologies are developed in order to reach these goals, and DNV as a Class society is developing frameworks for assurance of such systems. The certification of ships and vessels with a high degree of automation or autonomy needs an increased focus on software, an understanding of the human-to-machine interaction and the resulting ability to solve complex operations in a secure way. In this paper, a method for high-level risk analysis of the safety aspects of autonomous vessels combined with automatic simulation-based testing of a control system, is proposed.