Automatic T2* determination for quantification of iron load in heart and liver: a comparison between automatic inline Maximum Likelihood Estimate and the truncation and offset methods

Hedström, Erik; Voigt, Tobias; Greil, Gerald; Schaeffter, Tobias; Nagel, Eike

doi:10.1111/cpf.12303

Cited by 4 publications

(3 citation statements)

References 23 publications

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“…1 and produces a higher T2* value. Some study has suggested avoiding TE points exclusion when classic monoexponential evaluation shows normal T2* range when performing R 2 truncation [ 44 ].…”

Section: Discussionmentioning

confidence: 99%

“…Here, the comparison of pixel-wise fitting methods and the influence of noise and artifact in T2* quantification of the myocardium was limited to the bright blood mode. Even though a low NEX was performed in this study, an attempt to increase NEX might reduce noise but at the expense of increasing scanning time [ 15 , 44 ]. This study was conducted without enabling parallel imaging.…”

Section: Discussionmentioning

confidence: 99%

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T2* assessment of the three coronary artery territories of the left ventricular wall by different monoexponential truncation methods

Triadyaksa

Overbosch

Oudkerk

et al. 2022

Magn Reson Mater Phy

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Objectives This study aimed at evaluating left ventricular myocardial pixel-wise T2* using two truncation methods for different iron deposition T2* ranges and comparison of segmental T2* in different coronary artery territories. Material and methods Bright blood multi-gradient echo data of 30 patients were quantified by pixel-wise monoexponential T2* fitting with its R2 and SNR truncation. T2* was analyzed at different iron classifications. At low iron classification, T2* values were also analyzed by coronary artery territories. Results The right coronary artery has a significantly higher T2* value than the other coronary artery territories. No significant difference was found in classifying severe iron by the two truncation methods in any myocardial region, whereas in moderate iron, it is only apparent at septal segments. The R2 truncation produces a significantly higher T2* value than the SNR method when low iron is indicated. Conclusion Clear T2* differentiation between the three coronary territories by the two truncation methods is demonstrated. The two truncation methods can be used interchangeably in classifying severe and moderate iron deposition at the recommended septal region. However, in patients with low iron indication, different results by the two truncation methods can mislead the investigation of early iron level progression.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

T2* assessment of the three coronary artery territories of the left ventricular wall by different monoexponential truncation methods

Triadyaksa

Overbosch

Oudkerk

et al. 2022

Magn Reson Mater Phy

View full text Add to dashboard Cite

show abstract

“…The noise level is measured as part of the scan. This approach should be robust against noise floor estimation bias and therefore there is no need to exclude later echoes from the analysis [5,6].…”

Section: Notesmentioning

confidence: 99%

Analysis Protocols for MRI Mapping of the Blood Oxygenation–Sensitive Parameters T2* and T2 in the Kidney

Periquito

Starke

Santos

et al. 2021

Methods in Molecular Biology

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Renal hypoxia is generally accepted as a key pathophysiologic event in acute kidney injury of various origins and has also been suggested to play a role in the development of chronic kidney disease. Here we describe step-by-step data analysis protocols for MRI monitoring of renal oxygenation in rodents via the deoxyhemoglobin concentration sensitive MR parameters T2* and T2—a contrast mechanism known as the blood oxygenation level dependent (BOLD) effect.This chapter describes how to use the analysis tools provided by vendors of animal and clinical MR systems, as well as how to develop an analysis software. Aspects covered are: data quality checks, data exclusion, model fitting, fitting algorithm, starting values, effects of multiecho imaging, and result validation.This chapter is based upon work from the PARENCHIMA COST Action, a community-driven network funded by the European Cooperation in Science and Technology (COST) program of the European Union, which aims to improve the reproducibility and standardization of renal MRI biomarkers. This experimental protocol chapter is complemented by two separate chapters describing the basic concept and data analysis.

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Model Based Texture Features

Chaki

Dey²

2019

Texture Feature Extraction Techniques for Image Recognition

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Automatic T2* determination for quantification of iron load in heart and liver: a comparison between automatic inline Maximum Likelihood Estimate and the truncation and offset methods

Abstract: The automatic inline MLE method is comparable to the general reference standards for determining cardiac and liver T2* for ironload in man. An automatic inline method may simplify ironload assessment, particularly in centres seeing fewer cases.

Cited by 4 publications

References 23 publications

T2* assessment of the three coronary artery territories of the left ventricular wall by different monoexponential truncation methods

T2* assessment of the three coronary artery territories of the left ventricular wall by different monoexponential truncation methods

Analysis Protocols for MRI Mapping of the Blood Oxygenation–Sensitive Parameters T2* and T2 in the Kidney

Model Based Texture Features

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