Automatic Volumetry of the Cerebrospinal Fluid Space in Idiopathic Normal Pressure Hydrocephalus

Abstract

Objectives: To measure the cerebrospinal fluid (CSF) space volume in idiopathic normal pressure hydrocephalus (INPH), we developed a software that allows us to automatically measure the regional CSF space and compared the volumes of the ventricle systems (VS), Sylvian fissures (SF) and sulci at high convexity and midline (SHM) among INPH patients, Alzheimer's disease (AD) patients and healthy volunteers (HVs). Methods: Fifteen INPH patients, 15 AD patients and 15 HVs were retrospectively selected for this study. 3D-T1 MR images were obtained. We improved upon an automatic gray matter volume system to measure CSF spaces, adopting new regions for the template of INPH-characteristic CSF spaces and measured them. The VS, SF and SHM volumes were calculated relative to the intracranial volume. Results: The relative SHM volume of the INPH group (0.0237 ± 0.0064) was the smallest among the 3 groups (AD: 0.0477 ± 0.0109, HV: 0.0542 ± 0.0045). The VS (0.0499 ± 0.0135) and SF (0.0187 ± 0.0037) volumes of the INPH group were significantly larger than those of the AD (VS: 0.0311 ± 0.0075, SF: 0.0146 ± 0.0026) and HV groups (VS: 0.0167 ± 0.0065, SF: 0.0111 ± 0.017). Conclusion: Automatic volume measurement can be used to delineate the characteristic changes in CSF space in patients with INPH and is useful in the diagnosis of INPH.

High-Convexity Tightness Predicts the Shunt Response in Idiopathic Normal Pressure Hydrocephalus

“…26 The value of DESH in differentiating iNPH from other neurologic diseases has been confirmed by several studies. [27][28][29][30] Several diagnostic criteria for iNPH have recently been proposed. 1,8 One recent study reported that the effectiveness of shunt surgery for patients who were diagnosed according to one of these guidelines remained at 62.7% in terms of the mRS. 31 The incorporation of neuroimaging features that are predictive of surgical outcomes into the diagnostic criteria would thus improve the efficacy of shunt surgery.…”

Correlations of Ventricular Enlargement with Rheologically Active Surfactant Proteins in Cerebrospinal Fluid

“…Different approaches and indices for quantification of ventricular enlargement exist. Ventricular dilatation is most accurately estimated using volumetric, three dimensional approaches (Toma et al, 2011; Ishii et al, 2013; Ragan et al, 2015). …”

Body Metabolism and Exercise

“…Ishii et al (2013) described software that enables automatic measuring of the regional CSF space and comparing the volumes of ventricular systems, Sylvian fissures and sulci at high convexity in NPH patients, Alzheimer's patients, and healthy volunteers. The analysis was based on 1.5 and 3 tesla MRI.…”