Automating the transfusion service in the 21st century

Butch, Suzanne H.

doi:10.1111/j.1537-2995.2007.01635.x

Cited by 14 publications

(24 citation statements)

References 2 publications

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“…This issue results in human errors, indicating that such subjective interpretations should be avoided to guarantee safe transfusion [3]. Many laboratories in tertiary-care hospitals have begun to routinely use automated systems for this purpose [45], because of the increasing demand for tests such as routine blood group testing, cross-matching, and antibody screening [6]. The use of an automated system has many well-known advantages [678].…”

Section: Introductionmentioning

confidence: 99%

Comparative Analysis of Clinical Samples Showing Weak Serum Reaction on AutoVue System Causing ABO Blood Typing Discrepancies

Lee

Kim

et al. 2017

Ann Lab Med

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Background: ABO blood typing in pre-transfusion testing is a major component of the high workload in blood banks that therefore requires automation. We often experienced discrepant results from an automated system, especially weak serum reactions. We evaluated the discrepant results by the reference manual method to confirm ABO blood typing.Methods: In total, 13,113 blood samples were tested with the AutoVue system; all samples were run in parallel with the reference manual method according to the laboratory protocol.Results: The AutoVue system confirmed ABO blood typing of 12,816 samples (97.7%), and these results were concordant with those of the manual method. The remaining 297 samples (2.3%) showed discrepant results in the AutoVue system and were confirmed by the manual method. The discrepant results involved weak serum reactions ( < 2+ reaction grade), extra serum reactions, samples from patients who had received stem cell transplants, ABO subgroups, and specific system error messages. Among the 98 samples showing ≤ 1+ reaction grade in the AutoVue system, 70 samples (71.4%) showed a normal serum reaction (≥2+ reaction grade) with the manual method, and 28 samples (28.6%) showed weak serum reaction in both methods.Conclusions: ABO blood tying of 97.7% samples could be confirmed by the AutoVue system and a small proportion (2.3%) needed to be re-evaluated by the manual method. Samples with a 2+ reaction grade in serum typing do not need to be evaluated manually, while those with ≤ 1+ reaction grade do.

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Section: Introductionmentioning

confidence: 99%

Comparative Analysis of Clinical Samples Showing Weak Serum Reaction on AutoVue System Causing ABO Blood Typing Discrepancies

Lee

Kim

et al. 2017

Ann Lab Med

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“…The need of travel to the laboratory together with the times already required by current systems (about 15-20 min) [4,10] Table 1, led to respond timely to the needs in emergency situations; it was agreed that in these situations it is administered the blood type O negative (zero or negative), considered the universal donor, Table 1 Duration of ABO and Rh Tests on a Few Commercial Systems [10,13,15,18]. which provides less risk of incompatibilities [19][20][21][22][23].…”

Section: Introductionmentioning

confidence: 99%

“…To this end are available different test procedures, in particular the plate test, the tube test, the gel centrifugation test, and the micro plates test [1,2]. Considering these test procedures, the plate test and the tube test are those which are best suited for emergency situations since they require only between 5-10 min to perform the test procedure and obtain the results [3][4][5][6][7][8][9][10][11]. However, as these tests are manually performed, there is the possibility of human mistake or oversight, associated either to the test procedure, or to the reading and interpretation of results.…”

Section: Introductionmentioning

confidence: 99%

Mechatronic system for performing blood pre-transfusion tests

Ferraz

Carvalho

Machado

et al. 2016

Sensors and Actuators A: Physical

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“…Semi‐automatic and fully automatic analysers for processing blood‐typing cards using agglutination technology have demonstrated efficiency and reliability in providing test results that contribute to patient care. Many factors have to be considered when selecting a specific instrument including: time to first ABO/Rh(D) result, turnaround and throughput times, STAT execution, operator hands‐on time and instrument usability and reliability (Morelati et al ., ; Sandler et al ., ; Dada et al ., ; Wittmann et al ., ; Butch, ; Shin et al ., ). A fully automated system would also be expected to effectively manage laboratory workload without compromising accuracy, ensuring that validation and quality control activities have been successfully completed and allowing customisation to be effectively integrated into existing and future laboratory processes.…”

mentioning

confidence: 99%

Multicentre evaluation of Erytra Eflexis®, a benchtop fully automated analyser with a compact design for routine use in blood transfusion laboratory

Elliott

Carrascosa

Souchet

et al. 2019

Transfusion Medicine

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Objectives: Evaluation of the compact benchtop Erytra Eflexis ® automated analyser was performed at three health centres representing a range of routine transfusion workload.Background: Automation instruments with the simplicity and flexibility adequate for small-to mid-sized blood transfusion services are an unmet need. Methods: Performance in pre-transfusion testing (2109 ABO/D, 382 Rh/K phenotype, 2001 antibody screening, 113 antibody identification, 151 DAT, 88 extended phenotype; 655 cross matching) in comparison to Erytra ® as reference device was assessed. Throughput [time to first result (TTFR), final turn-around time (TAT), processing rate] was calculated; usability and adaptability in laboratory practice under routine and with emergency samples were surveyed.Results: Agreement between systems was 99·8% (11/5499 test discrepancies, all due to weak/doubtful positive reactions). Erytra Eflexis produced six true positives (two Rh/D, two B positives, two screening), four false positives (three screening and one cross matching) and one false negative (screening). Processing of eight routine samples with the Erytra Eflexis for ABO/Rh(D) and screening took 34-38 min and 32-37 min, respectively, independent of the simultaneous processing of a STAT sample, whether or not the incubator for STAT was reserved. In this scenario, a STAT sample requested within 2 min after the routine load was processed in 14-26 min. Processing rate tended to stabilise and optimise in the larger workloads, particularly in ABO/Rh(D)/K cards (16·7, 18 and 19·5 results/h for 10, 15 and 24 specimens, respectively). Conclusion:Erytra Eflexis analyser was found to be reliable and suitable for pre-transfusion routine tests performed in a small-/medium-sized blood transfusion laboratory.

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Automating the transfusion service in the 21st century

Cited by 14 publications

References 2 publications

Comparative Analysis of Clinical Samples Showing Weak Serum Reaction on AutoVue System Causing ABO Blood Typing Discrepancies

Comparative Analysis of Clinical Samples Showing Weak Serum Reaction on AutoVue System Causing ABO Blood Typing Discrepancies

Mechatronic system for performing blood pre-transfusion tests

Multicentre evaluation of Erytra Eflexis®, a benchtop fully automated analyser with a compact design for routine use in blood transfusion laboratory

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