This paper describes the development trend of automotive full-LCD instrument GUI application, analyzes the hierarchical structure of full-LCD instrument system, demonstrates the design and development process of GUI application based on GL Studio, and generates a full-LCD instrument GUI example with real-time rendering functions of dynamic graphics components and static graphics components. It effectively verifies the design idea of GUI application hierarchical architecture based on MVC architecture pattern and the feasibility of GUI application interface layout, visual communication, graphic component management and data-driven development strategy based on GL Studio, which has a certain reference value for the development of full-LCD instrument GUI design theory and engineering practice innovation.